This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
il-17a
IL-17A
IL-17A is produced by Th17 cells and ILC3; signals via IL-17RA/RC → NF-kB → neutrophil recruitment, AMP expression, and keratinocyte proliferation; drives psoriasis, ankylosing spondylitis, and psoriatic arthritis; secukinumab and ixekizumab are approved first-line biologics.
Entry Metadata
| Field | Value |
|---|---|
| ID | il-17a |
| Name | IL-17A |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201(2):233-240. · PubMed 15657292
- Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis — results of two phase 3 trials. N Engl J Med. 2014;371(4):326-338. · PubMed 25007392