Atlas One · Host Biology · Scale 07 — System

Psoriatic Arthritis

Seronegative inflammatory arthritis in ~30% of psoriasis patients; 5 clinical patterns; CASPAR criteria. Driven by IL-17A, IL-23, TNF-α, and IL-36 axes targeting skin, entheses, and joints. Approved biologics: anti-TNF, anti-IL-17A, anti-IL-23, anti-IL-12/23, JAK/TYK2 inhibitors.

Also known as: PsA, psoriatic spondylitis, psoriatic spondyloarthritis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
psoriatic-arthritis

Psoriatic Arthritis

Seronegative inflammatory arthritis in ~30% of psoriasis patients; 5 clinical patterns; CASPAR criteria. Driven by IL-17A, IL-23, TNF-α, and IL-36 axes targeting skin, entheses, and joints. Approved biologics: anti-TNF, anti-IL-17A, anti-IL-23, anti-IL-12/23, JAK/TYK2 inhibitors.

Entry Metadata

FieldValue
IDpsoriatic-arthritis
NamePsoriatic Arthritis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

modulated-byIl 36 modulated-byIl 17A modulated-byIl 23 modulated-byTnf Alpha connects-toHla B27 connects-toAnkylosing Spondylitis connects-toSkin connects-toPsoriasis connects-toMusculoskeletal System connects-toT Helper Cell connects-toRheumatoid Arthritis connects-toGout connects-toOsteoclast connects-toInflammatory Bowel Disease connects-toObesity connects-toType 2 Diabetes connects-toFibroblast connects-toEye connects-toCardiovascular System connects-toJak1 2 connects-toIntegumentary System connects-toImmune System connects-toOsteoblast connects-toIl 12 connects-toGut Microbiome connects-toCollagen connects-toMacrophage connects-toDendritic Cell connects-toT Cytotoxic Cell connects-toCalcium connects-toLarge Intestine connects-toSodium connects-toBone Marrow connects-toNeutrophil connects-toPhoton connects-toHeart connects-toVitamin D connects-toLiver connects-toLung connects-toAdipocyte connects-toAntibody connects-toEndothelial Cell connects-toMajor Depressive Disorder connects-toNash connects-toStat3 connects-toMast Cell connects-toWnt Beta Catenin connects-toRegulatory T Cell connects-toAtherosclerosis connects-toNf Kb connects-toFibromyalgia connects-toVenous Thromboembolism connects-toCandida Albicans connects-toOsteoporosis connects-toAnemia Of Chronic Disease connects-toTuberculosis connects-toHepatitis B Virus connects-toStroke connects-toVaricella Zoster Virus connects-toCkd connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toRespiratory System connects-toWound Healing connects-toRenal System connects-toNervous System connects-toLymphatic System connects-toAdalimumab connects-toEndocrine System connects-toReproductive System connects-toCancer Chemotherapy connects-toCortical Bone connects-toMycobacterium Tuberculosis connects-toCardiac Conduction System connects-toIga Nephropathy connects-toMultiple Sclerosis connects-toRankl connects-toArterial Wall connects-toKidney connects-toIntestinal Epithelium connects-toAtopic Dermatitis connects-toCovid 19 Disease connects-toIl 6 connects-toProstaglandins connects-toVegf connects-toIl 1B connects-toNlrp3 Inflammasome connects-toIfn Gamma connects-toS100A8 A9 connects-toCtla 4 connects-toCcl2 connects-toSclerostin connects-toIl 33 connects-toLeptin connects-toTgf Beta connects-toAdiponectin connects-toOsteopontin connects-toMyd88 connects-toIl 10 connects-toCgrp connects-toTlr4 connects-toMtor connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toSmad4 connects-toStat1 connects-toCgas Sting connects-toPerforin connects-toFoxo connects-toGsk 3B connects-toHif 1Alpha connects-toPik3Ca connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toComplement C3 connects-toCalcineurin connects-toAngiopoietin connects-toResistin connects-toNitric Oxide connects-toMhc Class Ii connects-toIl 2 connects-toTroponin Complex connects-toHemoglobin connects-toCholesterol connects-toXanthine Oxidase connects-toInsulin connects-toSubstance P connects-toPdgf connects-toPeripheral Nerve connects-toNeutrophil connects-toInflammatory Bowel Disease connects-toIl 4 connects-toIl 13 connects-toHepcidin connects-toType I Interferon connects-toIl 5 connects-toIge connects-toNatural Killer Cell connects-toB Cell connects-toPlasma Cell connects-toComplement C5 connects-toIl 31 connects-toSelenium connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toTslp connects-toHistamine connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toIodine connects-toMagnesium connects-toCopper connects-toIron connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin