Atlas One · Host Biology · Scale 03 — Molecular

IL-36

IL-36 cytokines (IL-36α/β/γ, chr2q12) signal via IL-36R/IL-1RAcP → NF-κB; IL-36Ra antagonist limits signaling. IL36RN loss-of-function drives generalized pustular psoriasis (GPP); spesolimab (anti-IL-36R; FDA 2022) targets GPP. Amplifies IL-17/IL-23 axis in skin and entheses.

Also known as: IL-36 alpha, IL-36 beta, IL-36 gamma, IL-36Ra, IL1F6, IL1F8, IL1F9, IL36RN

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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il-36

IL-36

IL-36 cytokines (IL-36α/β/γ, chr2q12) signal via IL-36R/IL-1RAcP → NF-κB; IL-36Ra antagonist limits signaling. IL36RN loss-of-function drives generalized pustular psoriasis (GPP); spesolimab (anti-IL-36R; FDA 2022) targets GPP. Amplifies IL-17/IL-23 axis in skin and entheses.

Entry Metadata

FieldValue
IDil-36
NameIL-36
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toPsoriatic Arthritis connects-toIl 17A connects-toIl 23 connects-toTnf Alpha modulatesNf Kb connects-toSkin connects-toAnkylosing Spondylitis

Sources