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hla-b27
HLA-B27
HLA-B27 is an MHC Class I allele (chr6p21.3) carried by ~8% of Europeans; present in ~90% of ankylosing spondylitis patients; misfolding in ER drives UPR → IL-23 → Th17 → IL-17A axis; also associates with reactive arthritis, anterior uveitis, and IBD spondyloarthropathy.
Entry Metadata
| Field | Value |
|---|---|
| ID | hla-b27 |
| Name | HLA-B27 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Brown MA, Bradbury LA. The genetics of ankylosing spondylitis and axial spondyloarthritis. Rheum Dis Clin North Am. 2018;44(2):229-244. · PubMed 29622524
- Reveille JD. Genetics of spondyloarthritis—beyond the MHC. Nat Rev Rheumatol. 2012;8(5):296-304. · PubMed 22450551
- Mear JP, Schreiber KL, Münz C, et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol. 1999;163(12):6665-70. · PubMed 10586063