Atlas One · Host Biology · Scale 03 — Molecular

Myostatin

Myostatin (GDF-8, MSTN, chr2q32.2) is a TGF-β superfamily inhibitor of skeletal muscle growth; ActRIIB → ALK4/5 → SMAD2/3 suppresses satellite cell proliferation and protein synthesis; loss-of-function causes double muscling; apitegromab blocks myostatin proform in SMA.

Also known as: myostatin, GDF-8, GDF8, growth differentiation factor 8, MSTN, myostatin propeptide

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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myostatin

Myostatin

Myostatin (GDF-8, MSTN, chr2q32.2) is a TGF-β superfamily inhibitor of skeletal muscle growth; ActRIIB → ALK4/5 → SMAD2/3 suppresses satellite cell proliferation and protein synthesis; loss-of-function causes double muscling; apitegromab blocks myostatin proform in SMA.

Entry Metadata

FieldValue
IDmyostatin
NameMyostatin
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesMusculoskeletal System connects-toTgf Beta connects-toIgf 1 connects-toActivin A

Sources