Atlas One · Host Biology · Scale 03 — Molecular

IGF-1

IGF-1 (IGF1, chr12q23.2) is the primary GH mediator; IGF-1R → IRS-1 → PI3K/Akt/mTOR drives growth, muscle anabolism, and bone formation; Laron syndrome = GH resistance, low IGF-1; serum IGF-1 screens acromegaly; teprotumumab (anti-IGF-1R) treats thyroid eye disease.

Also known as: IGF-1, insulin-like growth factor 1, IGF1, somatomedin C, IGF-I, sulfation factor

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
igf-1

IGF-1

IGF-1 (IGF1, chr12q23.2) is the primary GH mediator; IGF-1R → IRS-1 → PI3K/Akt/mTOR drives growth, muscle anabolism, and bone formation; Laron syndrome = GH resistance, low IGF-1; serum IGF-1 screens acromegaly; teprotumumab (anti-IGF-1R) treats thyroid eye disease.

Entry Metadata

FieldValue
IDigf-1
NameIGF-1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMusculoskeletal System connects-toMyostatin connects-toType 2 Diabetes modulated-byGrowth Hormone connects-toBrain connects-toAlzheimers Disease

Sources