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il-31
IL-31
IL-31 (IL31, chr12q24.31) is a Th2 cytokine signaling via IL-31RA/OSMR → JAK1/JAK2 → STAT3/STAT5; activates sensory neurons driving itch; nemolizumab (anti-IL-31RA) reduced prurigo nodularis itch 71% (OLYMPIA 2) and is approved for AD pruritus.
Entry Metadata
| Field | Value |
|---|---|
| ID | il-31 |
| Name | IL-31 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004;5(7):752-760. · PubMed 15184896
- Ständer S, Yosipovitch G, Legat FJ, et al. Trial of nemolizumab in moderate-to-severe prurigo nodularis. N Engl J Med. 2020;382(8):706-716. · PubMed 32053299
- Yosipovitch G, Ständer S, Kerby MB, et al. Nemolizumab in patients with moderate-to-severe atopic dermatitis: randomized, phase 3, ARCADIA 1 and ARCADIA 2 trials. J Am Acad Dermatol. 2023;89(1):38-49. · PubMed 36669666