Atlas One · Host Biology · Scale 07 — System

IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis globally; galactose-deficient IgA1 (Gd-IgA1) → mesangial immune complex deposition → complement + CCL2 → macrophage infiltration → fibrosis; sparsentan, iptacopan, and budesonide (Tarpeyo) are recently approved.

Also known as: IgAN, Berger disease, IgA glomerulonephritis, mesangial IgA nephropathy, IgA vasculitis nephritis, HSP nephritis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
iga-nephropathy

IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis globally; galactose-deficient IgA1 (Gd-IgA1) → mesangial immune complex deposition → complement + CCL2 → macrophage infiltration → fibrosis; sparsentan, iptacopan, and budesonide (Tarpeyo) are recently approved.

Entry Metadata

FieldValue
IDiga-nephropathy
NameIgA Nephropathy
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCcl2 connects-toCkd connects-toComplement C5 connects-toSecretory Iga connects-toComplement C3 connects-toTgf Beta connects-toBaff connects-toImmune Thrombocytopenia connects-toKidney connects-toPlasma Cell connects-toGlomerulus connects-toInflammatory Bowel Disease connects-toRenal System connects-toSystemic Lupus Erythematosus connects-toPodocyte connects-toAnca Vasculitis connects-toB Cell connects-toGut Microbiome connects-toLiver connects-toImmune System connects-toStreptococcus Pyogenes connects-toHypertension connects-toT Helper Cell connects-toFibrosis connects-toEndothelial Cell connects-toAngiotensin Ii connects-toErythrocyte connects-toSglt2 connects-toSmall Intestine connects-toMacrophage connects-toSodium connects-toSkin connects-toIron connects-toNeutrophil connects-toPhoton connects-toPotassium connects-toIntestinal Epithelium connects-toElectron connects-toLarge Intestine connects-toLung connects-toAntibody connects-toAlbumin connects-toVitamin D connects-toNash connects-toIl 6 connects-toRegulatory T Cell connects-toGerminal Center connects-toDendritic Cell connects-toSpleen connects-toIl 17A connects-toAnkylosing Spondylitis connects-toMast Cell connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toPneumocystis Jirovecii connects-toOsteoporosis connects-toHeart Failure connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toDigestive System connects-toMusculoskeletal System connects-toRespiratory System connects-toLymphatic System connects-toNervous System connects-toAce Inhibitors connects-toCardiovascular System connects-toCorticosteroids connects-toArbs connects-toPeyers Patches connects-toCancer Chemotherapy connects-toArterial Wall connects-toPsoriasis connects-toRheumatoid Arthritis connects-toEndothelin 1 connects-toHepatic Lobule connects-toPsoriatic Arthritis connects-toCovid 19 Disease connects-toSjogrens Syndrome connects-toHepatitis C connects-toIl 23 connects-toPdgf connects-toVegf connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toHif 1Alpha connects-toFactor H connects-toMhc Class Ii connects-toS100A8 A9 connects-toBtk connects-toTlr4 connects-toFcrn connects-toGlucocorticoid Receptor connects-toCollagen connects-toGalectin 3 connects-toC5Ar1 connects-toIl 10 connects-toIl 1B connects-toMyd88 connects-toJak1 2 connects-toSmad4 connects-toErk1 2 connects-toAkt connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toPik3Ca connects-toFoxo connects-toGsk 3B connects-toPerforin connects-toAmpk connects-toMtor connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toCd20 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toImmunoglobulin G connects-toHemoglobin connects-toIl 4 connects-toAldosterone connects-toIl 13 connects-toErythropoietin connects-toProstaglandins connects-toNitric Oxide connects-toXanthine Oxidase connects-toHepcidin connects-toPth connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIge connects-toNatural Killer Cell connects-toT Cytotoxic Cell connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTransferrin connects-toTslp connects-toHistamine connects-toBradykinin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toSelenium connects-toIodine connects-toMagnesium connects-toCopper connects-toZinc connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin