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iga-nephropathy
IgA Nephropathy
IgA nephropathy is the most common primary glomerulonephritis globally; galactose-deficient IgA1 (Gd-IgA1) → mesangial immune complex deposition → complement + CCL2 → macrophage infiltration → fibrosis; sparsentan, iptacopan, and budesonide (Tarpeyo) are recently approved.
Entry Metadata
| Field | Value |
|---|---|
| ID | iga-nephropathy |
| Name | IgA Nephropathy |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toCcl2
connects-toCkd
connects-toComplement C5
connects-toSecretory Iga
connects-toComplement C3
connects-toTgf Beta
connects-toBaff
connects-toImmune Thrombocytopenia
connects-toKidney
connects-toPlasma Cell
connects-toGlomerulus
connects-toInflammatory Bowel Disease
connects-toRenal System
connects-toSystemic Lupus Erythematosus
connects-toPodocyte
connects-toAnca Vasculitis
connects-toB Cell
connects-toGut Microbiome
connects-toLiver
connects-toImmune System
connects-toStreptococcus Pyogenes
connects-toHypertension
connects-toT Helper Cell
connects-toFibrosis
connects-toEndothelial Cell
connects-toAngiotensin Ii
connects-toErythrocyte
connects-toSglt2
connects-toSmall Intestine
connects-toMacrophage
connects-toSodium
connects-toSkin
connects-toIron
connects-toNeutrophil
connects-toPhoton
connects-toPotassium
connects-toIntestinal Epithelium
connects-toElectron
connects-toLarge Intestine
connects-toLung
connects-toAntibody
connects-toAlbumin
connects-toVitamin D
connects-toNash
connects-toIl 6
connects-toRegulatory T Cell
connects-toGerminal Center
connects-toDendritic Cell
connects-toSpleen
connects-toIl 17A
connects-toAnkylosing Spondylitis
connects-toMast Cell
connects-toNf Kb
connects-toVenous Thromboembolism
connects-toSepsis
connects-toAnemia Of Chronic Disease
connects-toPneumocystis Jirovecii
connects-toOsteoporosis
connects-toHeart Failure
connects-toAspergillus Fumigatus
connects-toMajor Depressive Disorder
connects-toIntegumentary System
connects-toDigestive System
connects-toMusculoskeletal System
connects-toRespiratory System
connects-toLymphatic System
connects-toNervous System
connects-toAce Inhibitors
connects-toCardiovascular System
connects-toCorticosteroids
connects-toArbs
connects-toPeyers Patches
connects-toCancer Chemotherapy
connects-toArterial Wall
connects-toPsoriasis
connects-toRheumatoid Arthritis
connects-toEndothelin 1
connects-toHepatic Lobule
connects-toPsoriatic Arthritis
connects-toCovid 19 Disease
connects-toSjogrens Syndrome
connects-toHepatitis C
connects-toIl 23
connects-toPdgf
connects-toVegf
connects-toTnf Alpha
connects-toNlrp3 Inflammasome
connects-toHif 1Alpha
connects-toFactor H
connects-toMhc Class Ii
connects-toS100A8 A9
connects-toBtk
connects-toTlr4
connects-toFcrn
connects-toGlucocorticoid Receptor
connects-toCollagen
connects-toGalectin 3
connects-toC5Ar1
connects-toIl 10
connects-toIl 1B
connects-toMyd88
connects-toJak1 2
connects-toSmad4
connects-toErk1 2
connects-toAkt
connects-toStat3
connects-toCgas Sting
connects-toStat1
connects-toPik3Ca
connects-toFoxo
connects-toGsk 3B
connects-toPerforin
connects-toAmpk
connects-toMtor
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toCd20
connects-toArid1A
connects-toCalcineurin
connects-toAdenosine
connects-toImmunoglobulin G
connects-toHemoglobin
connects-toIl 4
connects-toAldosterone
connects-toIl 13
connects-toErythropoietin
connects-toProstaglandins
connects-toNitric Oxide
connects-toXanthine Oxidase
connects-toHepcidin
connects-toPth
connects-toPotassium
connects-toCalcium
connects-toPhosphorus
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIge
connects-toNatural Killer Cell
connects-toT Cytotoxic Cell
connects-toC1 Esterase Inhibitor
connects-toPeriostin
connects-toTransferrin
connects-toTslp
connects-toHistamine
connects-toBradykinin
connects-toMelatonin
connects-toProlactin
connects-toOxytocin
connects-toTestosterone
connects-toSerotonin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toMagnesium
connects-toCopper
connects-toZinc
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toOxygen
connects-toCarbon
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toWnt Beta Catenin
connects-toRankl
connects-toIl 2
connects-toNotch
connects-toIgf 1
connects-toFibronectin
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
Sources
- Barratt J, Feehally J. IgA nephropathy. J Am Soc Nephrol. 2005;16(7):2088-2097. · PubMed 15987751
- Heerspink HJL, Radhakrishnan J, Alpers CE, et al. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial. Lancet. 2023;401(10388):1584-1594. · PubMed 37062299