Atlas One · Host Biology · Scale 07 — System

IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis globally; galactose-deficient IgA1 (Gd-IgA1) → mesangial immune complex deposition → complement + CCL2 → macrophage infiltration → fibrosis; sparsentan, iptacopan, and budesonide (Tarpeyo) are recently approved.

Also known as: IgAN, Berger disease, IgA glomerulonephritis, mesangial IgA nephropathy, IgA vasculitis nephritis, HSP nephritis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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iga-nephropathy

IgA Nephropathy

IgA nephropathy is the most common primary glomerulonephritis globally; galactose-deficient IgA1 (Gd-IgA1) → mesangial immune complex deposition → complement + CCL2 → macrophage infiltration → fibrosis; sparsentan, iptacopan, and budesonide (Tarpeyo) are recently approved.

Entry Metadata

FieldValue
IDiga-nephropathy
NameIgA Nephropathy
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCcl2 connects-toCkd connects-toComplement C5 connects-toSecretory Iga

Sources