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endothelin-1
Endothelin-1
Endothelin-1 (ET-1, EDN1) is the most potent endogenous vasoconstrictor; ETA/ETB receptor signaling drives sustained vasoconstriction, vascular remodeling, and fibrosis; bosentan and macitentan (dual ERAs) are first-line therapy for pulmonary arterial hypertension.
Entry Metadata
| Field | Value |
|---|---|
| ID | endothelin-1 |
| Name | Endothelin-1 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332(6163):411-415. · PubMed 2451132
- Galie N, Channick RN, Frantz RP, et al. Risk stratification and medical therapy of pulmonary arterial hypertension. Eur Respir J. 2019;53(1):1801889. · PubMed 30545974