Atlas One · Host Biology · Scale 03 — Molecular

SGLT2

SGLT2 is a sodium-glucose cotransporter in the proximal tubule reabsorbing ~90% of filtered glucose; SGLT2 inhibitors (dapagliflozin, empagliflozin) reduce blood glucose, intraglomerular pressure, and cardiac preload; proven to reduce CV death, HHF, and CKD progression.

Also known as: SGLT2, SLC5A2, sodium-glucose cotransporter 2, SGLT2 inhibitor, dapagliflozin target, empagliflozin target, canagliflozin target, gliflozin, SGLT2i

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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sglt2

SGLT2

SGLT2 is a sodium-glucose cotransporter in the proximal tubule reabsorbing ~90% of filtered glucose; SGLT2 inhibitors (dapagliflozin, empagliflozin) reduce blood glucose, intraglomerular pressure, and cardiac preload; proven to reduce CV death, HHF, and CKD progression.

Entry Metadata

FieldValue
IDsglt2
NameSGLT2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toType 2 Diabetes connects-toHeart Failure connects-toCkd connects-toNlrp3 Inflammasome

Sources