Atlas One · Host Biology · Scale 07 — System

ANCA Vasculitis

ANCA vasculitis (GPA, MPA, EGPA): small-vessel necrotizing vasculitis; anti-PR3 or anti-MPO IgG primes neutrophils via C5a/C5aR1 → NET formation → endothelial injury. Cyclophosphamide/rituximab induction; avacopan (steroid-sparing; FDA Oct 2021) and rituximab maintenance.

Also known as: ANCA vasculitis, AAV, GPA, MPA, EGPA, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis, Wegener's granulomatosis, Churg-Strauss syndrome, pauci-immune vasculitis, anti-PR3 vasculitis, anti-MPO vasculitis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
anca-vasculitis

ANCA Vasculitis

ANCA vasculitis (GPA, MPA, EGPA): small-vessel necrotizing vasculitis; anti-PR3 or anti-MPO IgG primes neutrophils via C5a/C5aR1 → NET formation → endothelial injury. Cyclophosphamide/rituximab induction; avacopan (steroid-sparing; FDA Oct 2021) and rituximab maintenance.

Entry Metadata

FieldValue
IDanca-vasculitis
NameANCA Vasculitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toC5Ar1 connects-toComplement C5 connects-toCd20 connects-toImmunoglobulin G connects-toNeutrophil connects-toKidney connects-toCkd connects-toGiant Cell Arteritis connects-toB Cell connects-toLung connects-toAsthma connects-toSkin connects-toMacrophage connects-toT Helper Cell connects-toPlasma Cell connects-toHepatitis B connects-toEndothelial Cell connects-toSystemic Lupus Erythematosus connects-toImmune System connects-toGlomerulus connects-toNervous System connects-toRespiratory System connects-toEye connects-toPeripheral Nerve connects-toIl 5 connects-toComplement C3 connects-toFibrosis connects-toRegulatory T Cell connects-toHeart connects-toNlrp3 Inflammasome connects-toDendritic Cell connects-toOxygen connects-toLarge Intestine connects-toBrain connects-toPhoton connects-toAlveolus connects-toIron connects-toElectron connects-toStomach connects-toSpleen connects-toAntibody connects-toNeuron connects-toBladder Cancer connects-toCortisol connects-toVenous Thromboembolism connects-toSmooth Muscle Cell connects-toPodocyte connects-toBaff connects-toInflammatory Bowel Disease connects-toIl 17A connects-toGerminal Center connects-toHeart Failure connects-toNf Kb connects-toSepsis connects-toStroke connects-toPneumocystis Jirovecii connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toAspergillus Fumigatus connects-toPulmonary Arterial Hypertension connects-toOsteoporosis connects-toIntegumentary System connects-toDigestive System connects-toVaricella Zoster Virus connects-toRenal System connects-toCardiovascular System connects-toEndocrine System connects-toMusculoskeletal System connects-toReproductive System connects-toCorticosteroids connects-toStaphylococcus Aureus connects-toRheumatoid Arthritis connects-toMycobacterium Tuberculosis connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toIga Nephropathy connects-toArterial Wall connects-toIntestinal Epithelium connects-toStimulant Use Disorder connects-toMyocardium connects-toHepatitis C connects-toDlbcl connects-toSystemic Sclerosis connects-toSjogrens Syndrome connects-toIl 6 connects-toTnf Alpha connects-toIfn Gamma connects-toIl 1B connects-toS100A8 A9 connects-toCcl2 connects-toFibrinogen connects-toBtk connects-toTlr4 connects-toThrombin connects-toGlucocorticoid Receptor connects-toFcrn connects-toMhc Class Ii connects-toTgf Beta connects-toFactor H connects-toCaspase 3 connects-toMyd88 connects-toJak1 2 connects-toIl 23 connects-toErk1 2 connects-toAkt connects-toGalectin 3 connects-toCgas Sting connects-toStat3 connects-toStat1 connects-toFoxo connects-toHif 1Alpha connects-toPerforin connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toArid1A connects-toCalcineurin connects-toType I Interferon connects-toIge connects-toIl 4 connects-toNitric Oxide connects-toHemoglobin connects-toIl 13 connects-toXanthine Oxidase connects-toIl 10 connects-toProstaglandins connects-toMast Cell connects-toHepcidin connects-toVegf connects-toAngiopoietin connects-toPd 1 connects-toCtla 4 connects-toIl 2 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toT Cytotoxic Cell connects-toIl 12 connects-toTslp connects-toPeriostin connects-toHistamine connects-toC1 Esterase Inhibitor connects-toSelenium connects-toTransferrin connects-toOsteopontin connects-toFibroblast connects-toCollagen connects-toBradykinin connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toCalcium connects-toZinc connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toCarbon connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf