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podocyte
Podocyte
Visceral epithelial cell of the renal glomerulus. Interdigitating foot processes form the slit diaphragm — the final protein-selectivity barrier of glomerular filtration. Terminally differentiated; loss causes proteinuria and nephrotic syndrome.
Entry Metadata
| Field | Value |
|---|---|
| ID | podocyte |
| Name | Podocyte |
| Status | draft |
| Last reviewed | 2026-06-04 |
| Atlas | 01-human |
| Scale | 04-cellular |
| Cell Ontology | CL:0000653 |
| Lineage | intermediate mesoderm — metanephric mesenchyme — renal vesicle — S-shaped body |
Cross-Atlas Connections
Sources
- Quaggin SE, Kreidberg JA. Development of the renal glomerulus: good neighbors and good fences. Development. 2008;135(4):609-20. · PubMed 18223199
- Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med. 2006;354(13):1387-401. · PubMed 16571882
- Kriz W, Lemley KV. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J Am Soc Nephrol. 2015;26(2):258-69. · PubMed 25060056
- Reiser J, Mundel P. Dual effects of cyclosporine A on glomerular podocytes. J Am Soc Nephrol. 2004;15(10):2682-8. · PubMed 15466274
- Hall JE. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021. Ch. 26-27.