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fibrosis
Fibrosis
Pathological ECM accumulation (collagen I/III) replacing functional parenchyma. Driven by TGF-β1/SMAD3: injury → macrophage/epithelial TGF-β → myofibroblast activation → collagen deposition. Affects liver, lung, kidney, heart, skin.
Entry Metadata
| Field | Value |
|---|---|
| ID | fibrosis |
| Name | Fibrosis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 05-tissue |