Atlas One · Host Biology · Scale 03 — Molecular

Pulmonary Surfactant

Phospholipid-protein mixture (~90% lipid, ~10% protein) secreted by type II pneumocytes. DPPC reduces alveolar surface tension per Laplace law, preventing collapse. SP-A/D mediate innate immunity; SP-B/C enable spreading. Deficiency causes NRDS.

Also known as: surfactant, pulmonary surfactant, DPPC, SP-A, SP-B

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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surfactant

Pulmonary Surfactant

Phospholipid-protein mixture (~90% lipid, ~10% protein) secreted by type II pneumocytes. DPPC reduces alveolar surface tension per Laplace law, preventing collapse. SP-A/D mediate innate immunity; SP-B/C enable spreading. Deficiency causes NRDS.

Entry Metadata

FieldValue
IDsurfactant
NamePulmonary Surfactant
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

expressed-byType Ii Pneumocyte modulatesLung modulatesAlveolus connects-toArds connects-toSars Cov 2 connects-toFibrosis connects-toInfluenza Ha

Sources