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type-ii-pneumocyte
Type II pneumocyte
Alveolar type II (AT2) cells — cuboidal surfactant-secreting cells (~5% of alveolar surface area, ~60% of alveolar epithelial cells by count). Synthesise pulmonary surfactant via lamellar bodies; regenerate alveolar epithelium after injury (alveolar stem cell).
Entry Metadata
| Field | Value |
|---|---|
| ID | type-ii-pneumocyte |
| Name | Type II pneumocyte |
| Status | draft |
| Last reviewed | 2026-06-03 |
| Atlas | 01-human |
| Scale | 04-cellular |
| Cell Ontology | CL:0002063 |
| Lineage | endoderm — foregut — lung endoderm → NKX2.1+ progenitor → AT2 |
Cross-Atlas Connections
Sources
- Fehrenbach H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res. 2001;2(1):33-46. · PubMed 11686863
- Whitsett JA, Wert SE, Trapnell BC. Genetic disorders influencing lung formation and function at birth. Hum Mol Genet. 2004;13 Spec No 2:R207-15. · PubMed 15358728
- Mason RJ. Biology of alveolar type II cells. Respirology. 2006;11(Suppl):S12-5. · PubMed 16423262
- Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal, and cancer. Nature. 2014;507(7491):190-4. · PubMed 24499815