Atlas One · Host Biology · Scale 03 — Molecular

Galectin-3

Galectin-3 (LGALS3) is a β-galactoside lectin secreted by macrophages driving TGF-β-amplified cardiac and hepatic fibrosis; elevated serum galectin-3 predicts HFpEF, HF mortality, and NASH fibrosis stage; galectin-3 inhibitors (belapectin) are in Phase 2 trials.

Also known as: galectin-3, LGALS3, Mac-2, CBP35, galactose-binding lectin, galectin, fibrosis biomarker, MFC, modified citrus pectin

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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galectin-3

Galectin-3

Galectin-3 (LGALS3) is a β-galactoside lectin secreted by macrophages driving TGF-β-amplified cardiac and hepatic fibrosis; elevated serum galectin-3 predicts HFpEF, HF mortality, and NASH fibrosis stage; galectin-3 inhibitors (belapectin) are in Phase 2 trials.

Entry Metadata

FieldValue
IDgalectin-3
NameGalectin-3
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHeart Failure connects-toNash connects-toTgf Beta connects-toNlrp3 Inflammasome

Sources