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cxcl12
CXCL12
CXCL12 (SDF-1, chr10q11.21) is a constitutive CXC chemokine; CXCR4 → Gαi → PI3K/Akt retains HSC in bone marrow; plerixafor (CXCR4 antagonist) mobilizes HSC for transplantation; CXCR4 drives cancer metastasis to CXCL12-rich organs and is the X4-tropic HIV-1 co-receptor.
Entry Metadata
| Field | Value |
|---|---|
| ID | cxcl12 |
| Name | CXCL12 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996;382(6592):635-638. · PubMed 8757135
- DiPersio JF, Stadtmauer EA, Nademanee A, et al. Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem-cell transplantation in patients with multiple myeloma. Blood. 2009;113(23):5720-5726. · PubMed 19363221