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resistin
Resistin
Resistin is a monocyte-secreted cytokine (RETN) that activates NF-κB → insulin resistance, endothelial dysfunction, and hepatic VLDL secretion; elevated in NASH, T2D, and rheumatoid arthritis; inhibits adiponectin signaling and promotes pro-inflammatory macrophage activation.
Entry Metadata
| Field | Value |
|---|---|
| ID | resistin |
| Name | Resistin |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307-312. · PubMed 11201732
- Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med. 2004;1(2):e45. · PubMed 15526055