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calcineurin
Calcineurin
Calcineurin (PP2B) is a Ca²⁺/calmodulin-activated phosphatase; dephosphorylates NFAT → nuclear entry → IL-2, IL-4, IFN-γ transcription in T cells. Blocked by cyclosporine·cyclophilin-A and tacrolimus·FKBP12 complexes; voclosporin FDA 2021 for lupus nephritis.
Entry Metadata
| Field | Value |
|---|---|
| ID | calcineurin |
| Name | Calcineurin |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Liu J, Farmer JD Jr, Lane WS, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66(4):807-815. · PubMed 1715244
- Crabtree GR, Olson EN. NFAT signaling: choreography of a transcriptional dance. Cell. 2002;109 Suppl:S67-79. · PubMed 11983154
- Rovin BH, Teng YKO, Ginzler EM, et al. Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1). Lancet. 2021;397(10279):2070-2080. · PubMed 33971155
- Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today. 1992;13(4):136-142. · PubMed 1374689