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il-12
IL-12
IL-12 (p70; IL12A+IL12B heterodimer) is the master Th1-polarizing cytokine; produced by dendritic cells → JAK2/TYK2/STAT4 → IFN-γ from NK/T cells; IL12B/IL12RB1 loss → Mendelian susceptibility to mycobacterial disease; ustekinumab (anti-p40) → TB reactivation risk.
Entry Metadata
| Field | Value |
|---|---|
| ID | il-12 |
| Name | IL-12 |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3(2):133-146. · PubMed 12563297
- Altare F, Durandy A, Lammas D, et al. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection. J Clin Invest. 1998;102(12):2035-2040. · PubMed 9854042