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adenosine
Adenosine
Purine nucleoside from ATP hydrolysis; A1R (Gi) mediates sleep pressure and neuroprotection; A2AR (Gs) modulates striatal dopamine via D2R heterodimers. Caffeine (A1R/A2AR antagonist) promotes wakefulness; istradefylline (A2AR antagonist) adjuncts levodopa in Parkinson's.
Entry Metadata
| Field | Value |
|---|---|
| ID | adenosine |
| Name | Adenosine |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors. Pharmacol Rev. 2011;63(1):1-34. · PubMed 21303899
- Porkka-Heiskanen T, Strecker RE, Thakkar M, et al. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 1997;276(5316):1265-1268. · PubMed 9157887
- Benarroch EE. Adenosine and its receptors: multiple modulatory functions and potential therapeutic targets for neurologic disease. Neurology. 2008;70(3):231-236. · PubMed 18195268