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axonal-transport
Axonal Transport
Bidirectional movement of cargoes along axonal microtubule tracks; kinesin drives anterograde delivery (synaptic vesicles, mitochondria) and dynein drives retrograde return (trophic signals, damaged organelles). Disrupted in Alzheimer's, ALS, and Huntington's.
Entry Metadata
| Field | Value |
|---|---|
| ID | axonal-transport |
| Name | Axonal Transport |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 05-tissue |
Cross-Atlas Connections
Sources
- Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009;10(10):682-696. · PubMed 19773780
- Maday S, Twelvetrees AE, Moughamian AJ, Holzbaur EL. Axonal transport: cargo-specific mechanisms of motility and regulation. Neuron. 2014;84(2):292-309. · PubMed 25374356
- Millecamps S, Julien JP. Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci. 2013;14(3):161-176. · PubMed 23361386