Atlas One · Host Biology · Scale 03 — Molecular

HTT

HTT encodes huntingtin, a HEAT-repeat scaffold protein; CAG repeat expansion ≥36 in exon 1 → polyglutamine-expanded mHTT protein aggregation → striatal medium spiny neuron degeneration → Huntington disease; repeat length inversely predicts age of onset.

Also known as: HTT, huntingtin, HD gene, IT15, polyglutamine HTT, CAG repeat HD, mHTT, huntingtin protein, polyQ expansion, HD CAG

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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htt

HTT

HTT encodes huntingtin, a HEAT-repeat scaffold protein; CAG repeat expansion ≥36 in exon 1 → polyglutamine-expanded mHTT protein aggregation → striatal medium spiny neuron degeneration → Huntington disease; repeat length inversely predicts age of onset.

Entry Metadata

FieldValue
IDhtt
NameHTT
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHuntingtons Disease connects-toAutophagy connects-toDopamine connects-toCaspase 3

Sources