Atlas One · Host Biology · Scale 03 — Molecular

MSH2

MSH2 (MutS Homolog 2) forms MutSα (MSH2-MSH6) and MutSβ (MSH2-MSH3) heterodimers for mismatch repair; germline MSH2 mutations cause Lynch syndrome (~31%); MMR LOF → MSI-H → elevated TMB → immunotherapy sensitivity; EPCAM deletions silence MSH2 epigenetically.

Also known as: MSH2, MSH2 mutation, MSH2 Lynch syndrome, MutSα, MSH2-MSH6, dMMR MSH2, MSH2 IHC, MMR MSH2, MSH2 mismatch repair, MSH2 Lynch cancer

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
msh2

MSH2

MSH2 (MutS Homolog 2) forms MutSα (MSH2-MSH6) and MutSβ (MSH2-MSH3) heterodimers for mismatch repair; germline MSH2 mutations cause Lynch syndrome (~31%); MMR LOF → MSI-H → elevated TMB → immunotherapy sensitivity; EPCAM deletions silence MSH2 epigenetically.

Entry Metadata

FieldValue
IDmsh2
NameMSH2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMlh1 connects-toPd 1 connects-toColorectal Cancer connects-toEndometrial Cancer

Sources