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npy
Neuropeptide Y
Neuropeptide Y (NPY); 36-aa pancreatic polypeptide family member; most abundant neuropeptide in the CNS. Orexigenic via Y1R/Y5R on PVN; anxiolytic via Y1R on amygdala; vasoconstrictor co-released with NE from sympathetic terminals; stress-resilience peptide.
Entry Metadata
| Field | Value |
|---|---|
| ID | npy |
| Name | Neuropeptide Y |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y — a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982;296(5858):659-660. · PubMed 6978320
- Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides. 2004;38(4):213-224. · PubMed 15337373
- Parker RM, Herzog H. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci. 1999;11(4):1431-1448. · PubMed 10103134