Atlas One · Host Biology · Scale 07 — System

Gambling Disorder

Gambling disorder (0.5-3% prevalence) is the prototypical behavioral addiction: dopamine reward dysregulation, near-miss effect, D2/D3R hypofunction, and loss-chasing. Opioid antagonists (naltrexone) have the best pharmacological evidence; CBT and peer support are first-line.

Also known as: gambling disorder, pathological gambling, problem gambling, gambling addiction, behavioral addiction, near-miss effect, naltrexone gambling

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
gambling-disorder

Gambling Disorder

Gambling disorder (0.5-3% prevalence) is the prototypical behavioral addiction: dopamine reward dysregulation, near-miss effect, D2/D3R hypofunction, and loss-chasing. Opioid antagonists (naltrexone) have the best pharmacological evidence; CBT and peer support are first-line.

Entry Metadata

FieldValue
IDgambling-disorder
NameGambling Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDopamine connects-toSerotonin connects-toNorepinephrine connects-toMu Opioid Receptor targetsBrain connects-toInternet Gaming Disorder connects-toLewy Body Dementia connects-toAlcohol Use Disorder connects-toStimulant Use Disorder connects-toMajor Depressive Disorder connects-toAttention Deficit Hyperactivity Disorder connects-toOpioid Use Disorder connects-toParkinsons Disease connects-toBipolar Disorder connects-toNeuron connects-toObsessive Compulsive Disorder connects-toGeneralized Anxiety Disorder connects-toBinge Eating Disorder connects-toGlutamate connects-toNervous System connects-toCannabis Use Disorder connects-toCortisol connects-toBorderline Personality Disorder connects-toHippocampus connects-toTestosterone connects-toPtsd connects-toInsomnia Disorder connects-toGaba connects-toEndocannabinoid connects-toSynapse connects-toCalcium connects-toMicroglia connects-toAdrenal Gland connects-toPhoton connects-toAstrocyte connects-toHeart connects-toMagnesium connects-toLiver connects-toLarge Intestine connects-toStomach connects-toMelatonin connects-toReproductive System connects-toEpinephrine connects-toCardiovascular System connects-toGut Microbiome connects-toOrexin connects-toBdnf connects-toSocial Anxiety Disorder connects-toOxytocin connects-toBulimia Nervosa connects-toNlrp3 Inflammasome connects-toSchizophrenia connects-toPanic Disorder connects-toAnorexia Nervosa connects-toHypertension connects-toStroke connects-toObesity connects-toHeart Failure connects-toType 2 Diabetes connects-toMigraine connects-toCopd connects-toDigestive System connects-toEndocrine System connects-toMusculoskeletal System connects-toImmune System connects-toRespiratory System connects-toVenous Thromboembolism connects-toIntegumentary System connects-toFluoxetine connects-toCrh connects-toGhrelin connects-toOligodendrocyte connects-toAutism Spectrum Disorder connects-toAlzheimers Disease connects-toNarcolepsy connects-toLeptin connects-toNpy connects-toMyocardium connects-toAtherosclerosis connects-toCardiac Conduction System connects-toNash connects-toCovid 19 Disease connects-toIntestinal Epithelium connects-toArterial Wall connects-toGlp 1 connects-toAcetylcholine connects-toIl 6 connects-toSerotonin Transporter connects-toAdenosine connects-toVasopressin connects-toGsk 3B connects-toIl 1B connects-toHistamine connects-toTnf Alpha connects-toEstrogen connects-toProlactin connects-toErk1 2 connects-toAkt connects-toGlucocorticoid Receptor connects-toMtor connects-toPik3Ca connects-toNf Kb connects-toPten connects-toJak1 2 connects-toGalectin 3 connects-toNtrk connects-toStat3 connects-toCgas Sting connects-toFoxo connects-toStat1 connects-toS100A8 A9 connects-toHif 1Alpha connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toCalcineurin connects-toComplement C3 connects-toProgesterone connects-toNitric Oxide connects-toInsulin connects-toAngiotensin Ii connects-toAldosterone connects-toIl 10 connects-toProstaglandins connects-toXanthine Oxidase connects-toCholesterol connects-toIl 4 connects-toZinc connects-toCopper connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toNeuron connects-toStimulant Use Disorder connects-toAttention Deficit Hyperactivity Disorder connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toFactor H connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toIron connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toChloride connects-toHydrogen connects-toPd 1 connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toRenin connects-toMyostatin