Atlas One · Host Biology · Scale 07 — System

Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is caused by germline TSC1 or TSC2 mutations; mTOR hyperactivation → hamartomas in brain (cortical tubers, SEGA), kidney (angiomyolipoma), lung (LAM), skin; everolimus/sirolimus FDA-approved; epilepsy and intellectual disability are common.

Also known as: TSC, tuberous sclerosis complex, tuberous sclerosis, TSC1 syndrome, TSC2 syndrome, SEGA TSC, angiomyolipoma TSC, LAM TSC, TSC brain, TSC epilepsy

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
tuberous-sclerosis-complex

Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is caused by germline TSC1 or TSC2 mutations; mTOR hyperactivation → hamartomas in brain (cortical tubers, SEGA), kidney (angiomyolipoma), lung (LAM), skin; everolimus/sirolimus FDA-approved; epilepsy and intellectual disability are common.

Entry Metadata

FieldValue
IDtuberous-sclerosis-complex
NameTuberous Sclerosis Complex
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTsc1 Tsc2 connects-toMtor connects-toAmpk connects-toRenal Cell Carcinoma connects-toEpilepsy connects-toAutism Spectrum Disorder connects-toPik3Ca connects-toVhl Disease connects-toSkin connects-toBrain

Sources