Atlas One · Host Biology · Scale 07 — System

Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is caused by germline TSC1 or TSC2 mutations; mTOR hyperactivation → hamartomas in brain (cortical tubers, SEGA), kidney (angiomyolipoma), lung (LAM), skin; everolimus/sirolimus FDA-approved; epilepsy and intellectual disability are common.

Also known as: TSC, tuberous sclerosis complex, tuberous sclerosis, TSC1 syndrome, TSC2 syndrome, SEGA TSC, angiomyolipoma TSC, LAM TSC, TSC brain, TSC epilepsy

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
tuberous-sclerosis-complex

Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is caused by germline TSC1 or TSC2 mutations; mTOR hyperactivation → hamartomas in brain (cortical tubers, SEGA), kidney (angiomyolipoma), lung (LAM), skin; everolimus/sirolimus FDA-approved; epilepsy and intellectual disability are common.

Entry Metadata

FieldValue
IDtuberous-sclerosis-complex
NameTuberous Sclerosis Complex
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTsc1 Tsc2 connects-toMtor connects-toAmpk connects-toRenal Cell Carcinoma connects-toEpilepsy connects-toAutism Spectrum Disorder connects-toPik3Ca connects-toVhl Disease connects-toSkin connects-toBrain connects-toNeurofibromatosis Type 1 connects-toCardiomyocyte connects-toSmooth Muscle Cell connects-toCowden Syndrome connects-toAstrocyte connects-toGorlin Syndrome connects-toNeuron connects-toKidney connects-toHeart connects-toLung connects-toEye connects-toAttention Deficit Hyperactivity Disorder connects-toVegf connects-toFibroblast connects-toBirt Hogg Dube Syndrome connects-toCollagen connects-toGlutamate connects-toAutophagy connects-toCalcium connects-toSynapse connects-toAkt connects-toPhosphorus connects-toAdipocyte connects-toLiver connects-toPhoton connects-toPancreas connects-toOligodendrocyte connects-toEndothelial Cell connects-toLarge Intestine connects-toElectron connects-toAntibody connects-toReproductive System connects-toNeutrophil connects-toGaba connects-toMicroglia connects-toGeneralized Anxiety Disorder connects-toEstrogen connects-toHif 1Alpha connects-toMast Cell connects-toStat3 connects-toNf Kb connects-toMajor Depressive Disorder connects-toCkd connects-toHypertension connects-toPneumocystis Jirovecii connects-toAspergillus Fumigatus connects-toType 2 Diabetes connects-toStroke connects-toIntegumentary System connects-toRespiratory System connects-toWound Healing connects-toNervous System connects-toCardiovascular System connects-toDigestive System connects-toLymphatic System connects-toMusculoskeletal System connects-toEndocrine System connects-toTargeted Therapy connects-toMen1 Syndrome connects-toCarney Complex connects-toNeurofibromatosis Type 2 connects-toLung Slice connects-toHippocampus connects-toMyocardium connects-toPulmonary Arterial Hypertension connects-toPeutz Jeghers Syndrome connects-toNeuroendocrine Tumors connects-toGlomerulus connects-toHepatic Lobule connects-toCardiac Conduction System connects-toArterial Wall connects-toCortical Bone connects-toCyclin D1 connects-toErk1 2 connects-toType Ii Pneumocyte connects-toMyc connects-toIgf 1 connects-toPdgf connects-toBdnf connects-toCdkn1B connects-toTgf Beta connects-toCalcineurin connects-toAngiopoietin connects-toCaspase 3 connects-toPten connects-toNotch connects-toCcl2 connects-toGsk 3B connects-toE2F1 connects-toNfe2L2 connects-toRb1 connects-toJak1 2 connects-toKras connects-toCgas Sting connects-toStat1 connects-toSmad4 connects-toFoxo connects-toCdk4 6 connects-toGalectin 3 connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toPerforin connects-toArid1A connects-toCcr5 connects-toIl 6 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toTroponin Complex connects-toActh connects-toMelatonin connects-toProgesterone connects-toInsulin connects-toHemoglobin connects-toNitric Oxide connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toCholesterol connects-toLeptin connects-toIron connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toEye connects-toRenal Cell Carcinoma connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toT Cytotoxic Cell connects-toDendritic Cell connects-toMacrophage connects-toComplement C3 connects-toC5Ar1 connects-toTslp connects-toHistamine connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr

Sources