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cdkn1b
CDKN1B
CDKN1B (p27KIP1) is a CIP/KIP CDK inhibitor that arrests G1/S by inhibiting CDK2-CyclinE and CDK4/6-CyclinD; SCF-SKP2 ubiquitinates phospho-Thr187 p27 for S-phase degradation; germline CDKN1B LOF = MEN4 syndrome; cytoplasmic p27 paradoxically promotes migration.
Entry Metadata
| Field | Value |
|---|---|
| ID | cdkn1b |
| Name | CDKN1B |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Polyak K, Lee MH, Erdjument-Bromage H, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78(1):59-66. · PubMed 8033212
- Pellegata NS, Quintanilla-Martinez L, Siggelkow H, et al. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci USA. 2006;103(42):15558-15563. · PubMed 17030811