Atlas One · Host Biology · Scale 03 — Molecular

CDKN1A

CDKN1A (p21/WAF1/CIP1) is the primary p53 transcriptional target that inhibits CDK2-CyclinE and CDK4/6-CyclinD to block G1/S and G2/M transitions; PCNA-binding C-terminus halts DNA replication; key mediator of growth arrest, senescence, and DNA damage checkpoint.

Also known as: CDKN1A, p21, WAF1, CIP1, p21WAF1, p21CIP1, CDKN1A p53 target, cyclin-dependent kinase inhibitor 1A, p21 senescence, p21 PCNA

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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cdkn1a

CDKN1A

CDKN1A (p21/WAF1/CIP1) is the primary p53 transcriptional target that inhibits CDK2-CyclinE and CDK4/6-CyclinD to block G1/S and G2/M transitions; PCNA-binding C-terminus halts DNA replication; key mediator of growth arrest, senescence, and DNA damage checkpoint.

Entry Metadata

FieldValue
IDcdkn1a
NameCDKN1A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toP53 connects-toRb1 connects-toMdm2 connects-toLi Fraumeni Syndrome connects-toCdk4 6 connects-toAtm connects-toCdkn2A

Sources