Atlas One · Host Biology · Scale 03 — Molecular

MEN1

MEN1 (menin) is a scaffold in the MLL1/MLL2-menin complex that writes H3K4me3 at CDKN1B and Hox loci; LOF → CDK4/6 derepression → neuroendocrine proliferation; germline MEN1 = MEN1 syndrome; somatic MEN1 loss in 70-90% pancreatic NETs; no catalytic activity.

Also known as: MEN1, menin, multiple endocrine neoplasia type 1 gene, MEN1 tumor suppressor, menin-MLL complex, menin scaffold, MEN1 LOF, MEN1 mutation, MEN1 pNET, KMT2A-menin

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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men1

MEN1

MEN1 (menin) is a scaffold in the MLL1/MLL2-menin complex that writes H3K4me3 at CDKN1B and Hox loci; LOF → CDK4/6 derepression → neuroendocrine proliferation; germline MEN1 = MEN1 syndrome; somatic MEN1 loss in 70-90% pancreatic NETs; no catalytic activity.

Entry Metadata

FieldValue
IDmen1
NameMEN1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCdkn2A connects-toSstr2 connects-toNeuroendocrine Tumors connects-toPancreatic Cancer

Sources