Atlas One · Host Biology · Scale 07 — System

MEN4 Syndrome

Multiple Endocrine Neoplasia type 4 (MEN4) is caused by germline CDKN1B (p27KIP1) mutations; pituitary adenomas, parathyroid tumors, and pancreatic NETs similar to MEN1 but driven by CDK inhibitor LOF; annual biochemical and MRI surveillance; rarer than MEN1.

Also known as: MEN4, multiple endocrine neoplasia type 4, MEN4 syndrome, CDKN1B MEN4, p27KIP1 syndrome, MEN4 pituitary, MEN4 parathyroid, CDKN1B multiple endocrine neoplasia, MEN4 CDKN1B germline

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
men4-syndrome

MEN4 Syndrome

Multiple Endocrine Neoplasia type 4 (MEN4) is caused by germline CDKN1B (p27KIP1) mutations; pituitary adenomas, parathyroid tumors, and pancreatic NETs similar to MEN1 but driven by CDK inhibitor LOF; annual biochemical and MRI surveillance; rarer than MEN1.

Entry Metadata

FieldValue
IDmen4-syndrome
NameMEN4 Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn1B connects-toMen1 connects-toMen1 Syndrome connects-toNeuroendocrine Tumors connects-toCalcium connects-toGrowth Hormone connects-toPancreas connects-toCarney Complex connects-toCdk4 6 connects-toProlactin connects-toEndocrine System connects-toPancreatic Cancer connects-toInsulin connects-toPheochromocytoma Paraganglioma connects-toVhl Disease connects-toAdrenal Gland connects-toCortisol connects-toThyroid connects-toOsteoporosis connects-toCyclin D1 connects-toStomach connects-toReproductive System connects-toRet connects-toThymus connects-toOsteoclast connects-toPth connects-toRb1 connects-toSstr2 connects-toKidney connects-toOsteoblast connects-toVegf connects-toPhosphorus connects-toBrain connects-toEndothelial Cell connects-toPhoton connects-toIgf 1 connects-toLiver connects-toElectron connects-toBone Marrow connects-toLung connects-toAntibody connects-toSmall Intestine connects-toNeuron connects-toVitamin D connects-toMtor connects-toBreast Cancer connects-toGastric Cancer connects-toThyroid Cancer connects-toMeningioma connects-toFoxo connects-toFibroblast connects-toTuberous Sclerosis Complex connects-toAkt connects-toStat3 connects-toCkd connects-toType 2 Diabetes connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toHypertension connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRenal System connects-toNervous System connects-toDigestive System connects-toMusculoskeletal System connects-toCardiovascular System connects-toIntegumentary System connects-toTargeted Therapy connects-toHelicobacter Pylori connects-toNeurofibromatosis Type 1 connects-toIslet Of Langerhans connects-toCowden Syndrome connects-toCancer Chemotherapy connects-toCortical Bone connects-toRetinoblastoma connects-toCdkn1A connects-toGlomerulus connects-toIntestinal Epithelium connects-toDicer1 Syndrome connects-toHepatic Lobule connects-toSerotonin connects-toEndocardium connects-toE2F1 connects-toHif 1Alpha connects-toTert connects-toMyc connects-toWnt Beta Catenin connects-toEzh2 connects-toDopamine connects-toHistamine connects-toRankl connects-toFoxo1 connects-toCalcitonin connects-toCxcl12 connects-toCalcium connects-toSmad4 connects-toGlucagon connects-toPik3Ca connects-toErk1 2 connects-toNotch connects-toPten connects-toPdgf connects-toKras connects-toGalectin 3 connects-toJak1 2 connects-toTgf Beta connects-toStat1 connects-toCgas Sting connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 6 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toProton connects-toInsulin Receptor connects-toTroponin Complex connects-toActh connects-toAldosterone connects-toNitric Oxide connects-toMagnesium connects-toGlp 1 connects-toIl 10 connects-toIl 4 connects-toIl 13 connects-toZinc connects-toCholesterol connects-toLeptin connects-toAdiponectin connects-toResistin connects-toT Cytotoxic Cell connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toMacrophage connects-toC5Ar1 connects-toTslp connects-toComplement C5 connects-toErythropoietin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toCopper connects-toIron connects-toChloride connects-toSulfur connects-toCarbon connects-toNitrogen connects-toOxygen connects-toHydrogen connects-toPd 1 connects-toAngiotensin Ii connects-toIl 2 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toSubstance P connects-toFgf23 connects-toNotch connects-toIgf 1 connects-toTgf Beta connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources