Atlas One · Host Biology · Scale 07 — System

MEN4 Syndrome

Multiple Endocrine Neoplasia type 4 (MEN4) is caused by germline CDKN1B (p27KIP1) mutations; pituitary adenomas, parathyroid tumors, and pancreatic NETs similar to MEN1 but driven by CDK inhibitor LOF; annual biochemical and MRI surveillance; rarer than MEN1.

Also known as: MEN4, multiple endocrine neoplasia type 4, MEN4 syndrome, CDKN1B MEN4, p27KIP1 syndrome, MEN4 pituitary, MEN4 parathyroid, CDKN1B multiple endocrine neoplasia, MEN4 CDKN1B germline

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
men4-syndrome

MEN4 Syndrome

Multiple Endocrine Neoplasia type 4 (MEN4) is caused by germline CDKN1B (p27KIP1) mutations; pituitary adenomas, parathyroid tumors, and pancreatic NETs similar to MEN1 but driven by CDK inhibitor LOF; annual biochemical and MRI surveillance; rarer than MEN1.

Entry Metadata

FieldValue
IDmen4-syndrome
NameMEN4 Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn1B connects-toMen1 connects-toMen1 Syndrome connects-toNeuroendocrine Tumors connects-toCalcium connects-toGrowth Hormone connects-toPancreas connects-toCarney Complex connects-toCdk4 6 connects-toProlactin connects-toEndocrine System connects-toPancreatic Cancer connects-toInsulin

Sources