Atlas One · Host Biology · Scale 03 — Molecular

FGF23

FGF23 is an osteocyte-secreted hormone that reduces renal phosphate reabsorption and inhibits vitamin D activation via FGFR1/αKlotho; elevated 100-1000× in CKD → drives secondary hyperparathyroidism, LVH, and mortality; burosumab (anti-FGF23) treats XLH-related rickets.

Also known as: FGF23, fibroblast growth factor 23, FGF-23, phosphatonin, XLH phosphate regulator, CKD-MBD mediator, hypophosphatemia FGF23

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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fgf23

FGF23

FGF23 is an osteocyte-secreted hormone that reduces renal phosphate reabsorption and inhibits vitamin D activation via FGFR1/αKlotho; elevated 100-1000× in CKD → drives secondary hyperparathyroidism, LVH, and mortality; burosumab (anti-FGF23) treats XLH-related rickets.

Entry Metadata

FieldValue
IDfgf23
NameFGF23
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCkd connects-toHeart Failure connects-toOsteoporosis connects-toAldosterone connects-toFgfr connects-toPhosphorus connects-toPth

Sources