Atlas One · Host Biology · Scale 07 — System

MEN1 Syndrome

Multiple Endocrine Neoplasia type 1 (MEN1) is caused by germline MEN1 mutations; triad of parathyroid adenomas (>95%), pituitary adenomas (20-65%), and pancreatic NETs (30-80%); everolimus FDA-approved for pNETs; annual biochemical + MRI surveillance.

Also known as: MEN1 syndrome, multiple endocrine neoplasia type 1, Wermer syndrome, MEN type 1, MEN-1, hereditary pNET, parathyroid-pituitary-pancreas syndrome, MEN1 hereditary cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
men1-syndrome

MEN1 Syndrome

Multiple Endocrine Neoplasia type 1 (MEN1) is caused by germline MEN1 mutations; triad of parathyroid adenomas (>95%), pituitary adenomas (20-65%), and pancreatic NETs (30-80%); everolimus FDA-approved for pNETs; annual biochemical + MRI surveillance.

Entry Metadata

FieldValue
IDmen1-syndrome
NameMEN1 Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMen1 connects-toSstr2 connects-toNeuroendocrine Tumors connects-toPancreatic Cancer connects-toMtor connects-toInsulin connects-toProlactin connects-toMen4 Syndrome connects-toCalcium connects-toPancreas connects-toCarney Complex connects-toEndocrine System connects-toGrowth Hormone connects-toPheochromocytoma Paraganglioma connects-toVhl Disease connects-toAdrenal Gland connects-toThyroid connects-toCortisol connects-toOsteoporosis connects-toDigestive System connects-toStomach connects-toIntegumentary System connects-toPth connects-toThymus connects-toOsteoclast connects-toKidney connects-toGlucagon connects-toHepatocyte connects-toPhosphorus connects-toOsteoblast connects-toVegf connects-toHydrogen connects-toSmall Intestine connects-toEndothelial Cell connects-toPhoton connects-toIgf 1 connects-toLiver connects-toElectron connects-toSkin connects-toBone Marrow connects-toAntibody connects-toLung connects-toBreast Cancer connects-toVitamin D connects-toReproductive System connects-toWnt Beta Catenin connects-toCdkn1B connects-toGastric Cancer connects-toMeningioma connects-toFibroblast connects-toCalcitonin connects-toNeurofibromatosis Type 1 connects-toStat3 connects-toEzh2 connects-toCkd connects-toType 2 Diabetes connects-toVenous Thromboembolism connects-toMajor Depressive Disorder connects-toHypertension connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRenal System connects-toNervous System connects-toMusculoskeletal System connects-toRespiratory System connects-toCardiovascular System connects-toLymphatic System connects-toTargeted Therapy connects-toHelicobacter Pylori connects-toTuberous Sclerosis Complex connects-toIslet Of Langerhans connects-toCowden Syndrome connects-toHlrcc connects-toCortical Bone connects-toCancer Chemotherapy connects-toBrain connects-toGlomerulus connects-toDicer1 Syndrome connects-toIntestinal Epithelium connects-toSerotonin connects-toHepatic Lobule connects-toEndocardium connects-toCyclin D1 connects-toAkt connects-toHif 1Alpha connects-toMyc connects-toCdk4 6 connects-toTert connects-toDopamine connects-toHistamine connects-toRankl connects-toCdkn1A connects-toFoxo connects-toSmad4 connects-toCalcium connects-toDnmt3A connects-toEstrogen connects-toPik3Ca connects-toE2F1 connects-toErk1 2 connects-toPdgf connects-toPten connects-toRb1 connects-toGalectin 3 connects-toJak1 2 connects-toTgf Beta connects-toStat1 connects-toCgas Sting connects-toNotch connects-toGsk 3B connects-toMdm2 connects-toPerforin connects-toSrc Kinase connects-toS100A8 A9 connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 6 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toProton connects-toInsulin Receptor connects-toTroponin Complex connects-toActh connects-toAldosterone connects-toNitric Oxide connects-toMagnesium connects-toGlp 1 connects-toIl 10 connects-toIl 4 connects-toIl 13 connects-toZinc connects-toCholesterol connects-toLeptin connects-toAdiponectin connects-toResistin connects-toT Cytotoxic Cell connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toMacrophage connects-toC5Ar1 connects-toTslp connects-toComplement C5 connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toCopper connects-toIron connects-toChloride connects-toSulfur connects-toCarbon connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toAngiotensin Ii connects-toIl 2 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toSubstance P connects-toFgf23 connects-toAndrogen Receptor connects-toNotch connects-toIgf 1 connects-toTgf Beta connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin

Sources