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e2f1
E2F1
E2F1 is the primary activating E2F transcription factor released from Rb upon CDK4/6-mediated Rb phosphorylation; drives S-phase genes (CCNE1, MCM2-7, PCNA); pro-apoptotic via ARF-p53; RB1 LOF → unchecked E2F1 → proliferation in retinoblastoma and diverse cancers.
Entry Metadata
| Field | Value |
|---|---|
| ID | e2f1 |
| Name | E2F1 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 1992;70(2):337-350. · PubMed 1638634
- DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med. 2006;6(7):739-748. · PubMed 17100600