Atlas One · Host Biology · Scale 07 — System

Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is caused by germline NF1 mutations; café-au-lait macules, neurofibromas, Lisch nodules, optic pathway gliomas; ~10% lifetime MPNST risk; 1/3000; selumetinib FDA-approved for NF1-associated plexiform neurofibromas in children (2020).

Also known as: NF1, neurofibromatosis type 1, von Recklinghausen disease, NF1 syndrome, NF1 germline, NF1 plexiform neurofibroma, NF1 MPNST, neurofibromatosis cancer risk, NF1 selumetinib

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
neurofibromatosis-type-1

Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is caused by germline NF1 mutations; café-au-lait macules, neurofibromas, Lisch nodules, optic pathway gliomas; ~10% lifetime MPNST risk; 1/3000; selumetinib FDA-approved for NF1-associated plexiform neurofibromas in children (2020).

Entry Metadata

FieldValue
IDneurofibromatosis-type-1
NameNeurofibromatosis Type 1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSpred1 connects-toNf1 connects-toKras connects-toMpnst connects-toPeripheral Nerve connects-toMast Cell connects-toGist connects-toNeurofibromatosis Type 2 connects-toSkin connects-toBrain connects-toPheochromocytoma Paraganglioma connects-toNoonan Syndrome connects-toBreast Cancer connects-toIdh Mutant Glioma connects-toRhabdomyosarcoma connects-toGorlin Syndrome connects-toNeuron connects-toGlioblastoma connects-toEye connects-toNervous System connects-toIntegumentary System connects-toMusculoskeletal System connects-toHypertension connects-toAstrocyte connects-toErk1 2 connects-toMtor connects-toOsteoblast connects-toGrowth Hormone connects-toMacrophage connects-toAkt connects-toAdrenal Gland connects-toCopper connects-toKidney connects-toEndothelial Cell connects-toPhoton connects-toFibroblast connects-toHeart connects-toElectron connects-toBone Marrow connects-toLung connects-toAntibody connects-toLarge Intestine connects-toVitamin D connects-toReproductive System connects-toAttention Deficit Hyperactivity Disorder connects-toOsteoclast connects-toCmml connects-toStroke connects-toAutism Spectrum Disorder connects-toEpilepsy connects-toCdkn2A connects-toNeuropathic Pain connects-toNf Kb connects-toMajor Depressive Disorder connects-toVenous Thromboembolism connects-toOsteoporosis connects-toAml connects-toMelanoma connects-toNeuroendocrine Tumors connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toCardiovascular System connects-toDigestive System connects-toRenal System connects-toRespiratory System connects-toImmune System connects-toTargeted Therapy connects-toTuberous Sclerosis Complex connects-toSchwannomatosis connects-toCancer Chemotherapy connects-toCortical Bone connects-toMen1 Syndrome connects-toArterial Wall connects-toNeuroblastoma connects-toLi Fraumeni Syndrome connects-toHippocampus connects-toDiffuse Midline Glioma connects-toMyocardium connects-toLynch Syndrome connects-toVhl Disease connects-toSynapse connects-toBraf connects-toCdk4 6 connects-toPdgf connects-toMyc connects-toVegf connects-toHif 1Alpha connects-toKit connects-toGaba connects-toRankl connects-toCcl2 connects-toCxcl12 connects-toSubstance P connects-toNorepinephrine connects-toBdnf connects-toDnmt3A connects-toPik3Ca connects-toP53 connects-toE2F1 connects-toRb1 connects-toMdm2 connects-toEzh2 connects-toGalectin 3 connects-toTgf Beta connects-toStat3 connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toSrc Kinase connects-toS100A8 A9 connects-toPerforin connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toPtpn11 connects-toLztr1 connects-toNitric Oxide connects-toEstrogen connects-toProgesterone connects-toAngiotensin Ii connects-toCollagen connects-toIl 10 connects-toTroponin Complex connects-toHistamine connects-toIl 4 connects-toProstaglandins connects-toIl 13 connects-toMast Cell connects-toGist connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toT Helper Cell connects-toDendritic Cell connects-toB Cell connects-toNatural Killer Cell connects-toComplement C3 connects-toTslp connects-toBradykinin connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toComplement C5 connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toZinc connects-toPotassium connects-toCalcium connects-toCarbon connects-toChloride connects-toHydrogen connects-toIron connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr

Sources