Atlas One · Host Biology · Scale 07 — System

Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is caused by germline NF1 mutations; café-au-lait macules, neurofibromas, Lisch nodules, optic pathway gliomas; ~10% lifetime MPNST risk; 1/3000; selumetinib FDA-approved for NF1-associated plexiform neurofibromas in children (2020).

Also known as: NF1, neurofibromatosis type 1, von Recklinghausen disease, NF1 syndrome, NF1 germline, NF1 plexiform neurofibroma, NF1 MPNST, neurofibromatosis cancer risk, NF1 selumetinib

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
neurofibromatosis-type-1

Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is caused by germline NF1 mutations; café-au-lait macules, neurofibromas, Lisch nodules, optic pathway gliomas; ~10% lifetime MPNST risk; 1/3000; selumetinib FDA-approved for NF1-associated plexiform neurofibromas in children (2020).

Entry Metadata

FieldValue
IDneurofibromatosis-type-1
NameNeurofibromatosis Type 1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSpred1 connects-toNf1 connects-toKras connects-toMpnst connects-toPeripheral Nerve connects-toMast Cell connects-toGist connects-toNeurofibromatosis Type 2 connects-toSkin connects-toBrain

Sources