Atlas One · Host Biology · Scale 03 — Molecular

PTPN11

PTPN11 (SHP2) is a non-receptor protein tyrosine phosphatase that activates RAS-MAPK signaling via GAB1/IRS-1 dephosphorylation; germline GOF mutations → Noonan syndrome; somatic PTPN11 GOF → JMML and AML; SHP2 inhibitors (SHP099, RMC-4630) are in clinical development.

Also known as: PTPN11, SHP2, SHP-2, PTPN11 Noonan, SHP2 Noonan, PTPN11 JMML, SHP2 RAS, PTPN11 leukemia, SHP2 inhibitor, RASopathy PTPN11

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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ptpn11

PTPN11

PTPN11 (SHP2) is a non-receptor protein tyrosine phosphatase that activates RAS-MAPK signaling via GAB1/IRS-1 dephosphorylation; germline GOF mutations → Noonan syndrome; somatic PTPN11 GOF → JMML and AML; SHP2 inhibitors (SHP099, RMC-4630) are in clinical development.

Entry Metadata

FieldValue
IDptpn11
NamePTPN11
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toNoonan Syndrome connects-toLztr1 connects-toKras connects-toNf1

Sources