Atlas One · Host Biology · Scale 03 — Molecular

NF1

NF1 (neurofibromin) is a RasGAP; LOF → sustained RAS-GTP → MAPK/PI3K hyperactivation; germline NF1 syndrome: café-au-lait macules, neurofibromas, MPNST risk ~10%; somatic NF1 loss in GBM, NSCLC, melanoma; MEK inhibitor selumetinib FDA-approved for NF1 plexiform neurofibromas.

Also known as: NF1, neurofibromin, neurofibromatosis type 1 gene, NF1 RasGAP, neurofibromatosis 1, NF1 tumor suppressor, NF1 MPNST, NF1 plexiform neurofibroma, NF1 GBM, RasGAP NF1

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
nf1

NF1

NF1 (neurofibromin) is a RasGAP; LOF → sustained RAS-GTP → MAPK/PI3K hyperactivation; germline NF1 syndrome: café-au-lait macules, neurofibromas, MPNST risk ~10%; somatic NF1 loss in GBM, NSCLC, melanoma; MEK inhibitor selumetinib FDA-approved for NF1 plexiform neurofibromas.

Entry Metadata

FieldValue
IDnf1
NameNF1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toKras connects-toErk1 2 connects-toMtor connects-toEgfr connects-toBraf connects-toNf2 connects-toP53

Sources