Atlas One · Host Biology · Scale 07 — System

Diffuse Midline Glioma

Diffuse midline glioma (H3K27M+) is a WHO Grade 4 pediatric/young adult brain tumor defined by H3K27M mutation; DIPG, thalamic, and spinal cord locations; median OS 12-15 months; ONC201 (imipridone) FDA-approved for relapsed/refractory H3K27M+ DMG; no curative systemic therapy.

Also known as: DMG, diffuse midline glioma, DIPG, diffuse intrinsic pontine glioma, H3K27M glioma, thalamic glioma H3K27M, H3K27M-altered glioma, pediatric midline glioma, pontine glioma, H3.3K27M brain tumor

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
diffuse-midline-glioma

Diffuse Midline Glioma

Diffuse midline glioma (H3K27M+) is a WHO Grade 4 pediatric/young adult brain tumor defined by H3K27M mutation; DIPG, thalamic, and spinal cord locations; median OS 12-15 months; ONC201 (imipridone) FDA-approved for relapsed/refractory H3K27M+ DMG; no curative systemic therapy.

Entry Metadata

FieldValue
IDdiffuse-midline-glioma
NameDiffuse Midline Glioma
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toH3K27M connects-toEzh2 connects-toCdkn2A connects-toPdgf connects-toNf1 connects-toPik3Ca connects-toGlioblastoma connects-toBrain connects-toOligodendrocyte connects-toMicroglia connects-toMedulloblastoma connects-toAstrocyte connects-toPhoton connects-toIdh Mutant Glioma connects-toAtypical Teratoid Rhabdoid Tumor connects-toNeuron connects-toP53 connects-toCdk4 6 connects-toMtor connects-toNervous System connects-toLi Fraumeni Syndrome connects-toProton connects-toSynapse connects-toT Cytotoxic Cell connects-toGlutamate connects-toDopamine connects-toEgfr connects-toNatural Killer Cell connects-toCalcium connects-toVegf connects-toNf Kb connects-toEye connects-toLung connects-toEndothelial Cell connects-toHeart connects-toPeripheral Nerve connects-toActivin A connects-toElectron connects-toPotassium connects-toSodium connects-toAntibody connects-toStomach connects-toNeutrophil connects-toEndocrine System connects-toMyc connects-toRegulatory T Cell connects-toTgf Beta connects-toMacrophage connects-toNeurofibromatosis Type 1 connects-toAtrx connects-toEpilepsy connects-toNeuropathic Pain connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toStroke connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toType 2 Diabetes connects-toAspergillus Fumigatus connects-toWound Healing connects-toRespiratory System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toIntegumentary System connects-toImmune System connects-toCardiovascular System connects-toReproductive System connects-toPneumocystis Jirovecii connects-toTargeted Therapy connects-toCar T connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toAxonal Transport connects-toNeuroblastoma connects-toBdnf connects-toTert connects-toHippocampus connects-toChordoma connects-toMeningioma connects-toPcnsl connects-toCyclin D1 connects-toAkt connects-toIgf 1 connects-toHif 1Alpha connects-toMet connects-toNtrk connects-toCcl2 connects-toErk1 2 connects-toE2F1 connects-toCxcl12 connects-toCaspase 3 connects-toRad51 connects-toCalcium connects-toPerforin connects-toDnmt3A connects-toPten connects-toNotch connects-toRb1 connects-toKras connects-toJak1 2 connects-toBcl 2 connects-toSmad4 connects-toGalectin 3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toWnt Beta Catenin connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toIl 2 connects-toMhc Class Ii connects-toPd 1 connects-toIl 10 connects-toGaba connects-toNitric Oxide connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toAcetylcholine connects-toIron connects-toSerotonin connects-toNorepinephrine connects-toCholesterol connects-toMicroglia connects-toGlioblastoma connects-toPhoton connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toC5Ar1 connects-toT Helper Cell connects-toDendritic Cell connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toProlactin connects-toTestosterone connects-toIodine connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toResistin connects-toCortisol