Atlas One · Host Biology · Scale 07 — System

IDH-Mutant Glioma

IDH-mutant glioma (Grade 2-3) defined by IDH1/2 mutations; 2-HG → TET2 inhibition → G-CIMP hypermethylation; WHO 2021 separates astrocytoma (ATRX LOF) from oligodendroglioma (1p/19q codeletion); vorasidenib FDA-approved August 2024 (INDIGO trial); median OS ~10-15 years.

Also known as: IDH-mutant glioma, IDH glioma, IDH mutant astrocytoma, IDH mutant oligodendroglioma, lower grade glioma, LGG, diffuse glioma IDH, IDH1 glioma, IDH1 R132H glioma, Grade 2 glioma vorasidenib

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
idh-mutant-glioma

IDH-Mutant Glioma

IDH-mutant glioma (Grade 2-3) defined by IDH1/2 mutations; 2-HG → TET2 inhibition → G-CIMP hypermethylation; WHO 2021 separates astrocytoma (ATRX LOF) from oligodendroglioma (1p/19q codeletion); vorasidenib FDA-approved August 2024 (INDIGO trial); median OS ~10-15 years.

Entry Metadata

FieldValue
IDidh-mutant-glioma
NameIDH-Mutant Glioma
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toAtrx connects-toIdh1 connects-toTet2 connects-toCdkn2A connects-toBrain connects-toGlioblastoma connects-toAstrocyte connects-toMedulloblastoma connects-toAml connects-toCholangiocarcinoma connects-toOligodendrocyte connects-toEpilepsy connects-toDiffuse Midline Glioma connects-toPhoton connects-toLi Fraumeni Syndrome connects-toNeuron connects-toIdh2 connects-toP53 connects-toTert connects-toProton connects-toCarbon connects-toNervous System connects-toHlrcc connects-toT Cytotoxic Cell connects-toGlutamate connects-toMicroglia connects-toRegulatory T Cell connects-toMtor connects-toSynapse connects-toCalcium connects-toDendritic Cell connects-toIron connects-toMacrophage connects-toVegf connects-toHippocampus connects-toEye connects-toEndothelial Cell connects-toElectron connects-toPotassium connects-toLung connects-toAntibody connects-toMagnesium connects-toNeutrophil connects-toReproductive System connects-toDnmt3A connects-toT Helper Cell connects-toEgfr connects-toNatural Killer Cell connects-toAtp connects-toHif 1Alpha connects-toStroke connects-toNeuropathic Pain connects-toNlrp3 Inflammasome connects-toVenous Thromboembolism connects-toSepsis connects-toPneumocystis Jirovecii connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toType 2 Diabetes connects-toAspergillus Fumigatus connects-toWound Healing connects-toEndocrine System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toImmune System connects-toMusculoskeletal System connects-toIntegumentary System connects-toCardiovascular System connects-toRespiratory System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toLymphatic System connects-toCollagen connects-toCml connects-toCmml connects-toBdnf connects-toMds connects-toAxonal Transport connects-toPheochromocytoma Paraganglioma connects-toColorectal Cancer connects-toArterial Wall connects-toEzh2 connects-toAkt connects-toMyc connects-toCdk4 6 connects-toCyclin D1 connects-toPdgf connects-toRad51 connects-toCcl2 connects-toErk1 2 connects-toEgln1 connects-toCxcl12 connects-toCaspase 3 connects-toPerforin connects-toCgas Sting connects-toGalectin 3 connects-toPik3Ca connects-toE2F1 connects-toNotch connects-toRb1 connects-toKras connects-toNfe2L2 connects-toTgf Beta connects-toStat3 connects-toPten connects-toStat1 connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toPd 1 connects-toIl 10 connects-toGaba connects-toNitric Oxide connects-toProstaglandins connects-toIl 4 connects-toXanthine Oxidase connects-toIl 13 connects-toAcetylcholine connects-toMagnesium connects-toCholesterol connects-toSerotonin connects-toNorepinephrine connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIl 5 connects-toIl 23 connects-toIge connects-toC5Ar1 connects-toMast Cell connects-toB Cell connects-toComplement C5 connects-toFactor H connects-toVitamin D connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toErythropoietin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toTestosterone connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toHydrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources