Atlas One · Host Biology · Scale 07 — System

Medulloblastoma

Medulloblastoma is the most common pediatric brain tumor; 4 molecular subgroups: WNT (~10%, OS ~95%), SHH (~38%), Group 3 (~25%, MYC-amplified, worst prognosis), Group 4 (~35%); surgery + CSI + chemotherapy; SHH MB responsive to SMO inhibitors; infant MB: chemo without radiation.

Also known as: medulloblastoma, MB, pediatric medulloblastoma, SHH medulloblastoma, WNT medulloblastoma, Group 3 medulloblastoma, cerebellar medulloblastoma, MBEN

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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medulloblastoma

Medulloblastoma

Medulloblastoma is the most common pediatric brain tumor; 4 molecular subgroups: WNT (~10%, OS ~95%), SHH (~38%), Group 3 (~25%, MYC-amplified, worst prognosis), Group 4 (~35%); surgery + CSI + chemotherapy; SHH MB responsive to SMO inhibitors; infant MB: chemo without radiation.

Entry Metadata

FieldValue
IDmedulloblastoma
NameMedulloblastoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPtch1 connects-toMyc connects-toWnt Beta Catenin connects-toP53 connects-toBrain connects-toGorlin Syndrome connects-toLi Fraumeni Syndrome connects-toIdh Mutant Glioma connects-toAtypical Teratoid Rhabdoid Tumor connects-toNeuron

Sources