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sufu
SUFU
SUFU (Suppressor of Fused) sequesters GLI1/GLI2/GLI3 in the cytoplasm to block Hedgehog target genes; SMO activation dissociates SUFU-GLI → GLI nuclear → BCC/medulloblastoma program; LOF → constitutive HH signaling; germline SUFU = elevated desmoplastic medulloblastoma risk.
Entry Metadata
| Field | Value |
|---|---|
| ID | sufu |
| Name | SUFU |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet. 2002;31(3):306-310. · PubMed 12068298
- Brugières L, Pierron G, Chompret A, et al. Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. J Med Genet. 2010;47(2):142-144. · PubMed 19903819