Atlas One · Host Biology · Scale 03 — Molecular

PTCH1

PTCH1 (Patched 1) is the HH receptor; LOF → constitutive SMO → GLI1/2 transcription; germline PTCH1 mutations cause Gorlin syndrome (BCCs, SHH medulloblastoma); somatic PTCH1 LOF in ~90% sporadic BCC; SMO inhibitors (vismodegib, sonidegib) restore PTCH1-like SMO inhibition.

Also known as: PTCH1, Patched 1, PTCH, hedgehog receptor, PTCH1 Gorlin, basal cell nevus syndrome, PTCH1 medulloblastoma, sonic hedgehog pathway

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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ptch1

PTCH1

PTCH1 (Patched 1) is the HH receptor; LOF → constitutive SMO → GLI1/2 transcription; germline PTCH1 mutations cause Gorlin syndrome (BCCs, SHH medulloblastoma); somatic PTCH1 LOF in ~90% sporadic BCC; SMO inhibitors (vismodegib, sonidegib) restore PTCH1-like SMO inhibition.

Entry Metadata

FieldValue
IDptch1
NamePTCH1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toSmo connects-toMyc connects-toRb1 connects-toBcl 2 connects-toGorlin Syndrome connects-toBasal Cell Carcinoma connects-toSufu

Sources