Atlas One · Host Biology · Scale 03 — Molecular

SMO

Smoothened receptor in the Hedgehog pathway; activated when PTCH1 releases SMO repression after HH ligand binding → GLI transcription factors → BCL-2, cyclin D1, and MYC. Mutated in ~40% of sporadic BCC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Also known as: SMO, Smoothened, SMOH, Hedgehog pathway, GLI signaling, Hh signaling, SHH pathway receptor, frizzled-class GPCR

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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smo

SMO

Smoothened receptor in the Hedgehog pathway; activated when PTCH1 releases SMO repression after HH ligand binding → GLI transcription factors → BCL-2, cyclin D1, and MYC. Mutated in ~40% of sporadic BCC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Entry Metadata

FieldValue
IDsmo
NameSMO
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWnt Beta Catenin connects-toNotch connects-toMyc connects-toBcl 2 connects-toPtch1 connects-toBasal Cell Carcinoma connects-toSufu

Sources