Atlas One · Host Biology · Scale 07 — System

Gorlin Syndrome

Gorlin syndrome (NBCCS) is caused by germline PTCH1 (~85%) or SUFU (~2%) mutations; multiple BCCs, odontogenic keratocysts, calcified falx cerebri, medulloblastoma (~5%); radiation avoidance is critical; vismodegib FDA-approved to reduce BCC burden in Gorlin patients.

Also known as: Gorlin syndrome, NBCCS, nevoid basal cell carcinoma syndrome, Basal Cell Nevus Syndrome, PTCH1 Gorlin, Gorlin-Goltz syndrome, Gorlin medulloblastoma, hereditary BCC, Gorlin PTCH1 SUFU

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
gorlin-syndrome

Gorlin Syndrome

Gorlin syndrome (NBCCS) is caused by germline PTCH1 (~85%) or SUFU (~2%) mutations; multiple BCCs, odontogenic keratocysts, calcified falx cerebri, medulloblastoma (~5%); radiation avoidance is critical; vismodegib FDA-approved to reduce BCC burden in Gorlin patients.

Entry Metadata

FieldValue
IDgorlin-syndrome
NameGorlin Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSufu connects-toPtch1 connects-toSmo connects-toBasal Cell Carcinoma connects-toMedulloblastoma connects-toVegf connects-toSkin connects-toFibroblast connects-toP53 connects-toRhabdomyosarcoma connects-toMeningioma connects-toOsteoblast connects-toCardiomyocyte connects-toLi Fraumeni Syndrome connects-toNeurofibromatosis Type 1 connects-toOvarian Cancer connects-toPhoton connects-toWnt Beta Catenin connects-toEye connects-toIntegumentary System connects-toMusculoskeletal System connects-toNervous System connects-toCalcium connects-toReproductive System connects-toBrain connects-toMycn connects-toMtor connects-toRegulatory T Cell connects-toNf Kb connects-toMacrophage connects-toOxygen connects-toHeart connects-toFibrosis connects-toPhosphorus connects-toNeuron connects-toCyclin D1 connects-toLarge Intestine connects-toElectron connects-toBone Marrow connects-toLung connects-toAntibody connects-toCollagen connects-toStomach connects-toAkt connects-toOsteoclast connects-toT Cytotoxic Cell connects-toBcl 2 connects-toEndothelial Cell connects-toCowden Syndrome connects-toCdkn2A connects-toHeart Failure connects-toProton connects-toStat3 connects-toSepsis connects-toAutism Spectrum Disorder connects-toWound Healing connects-toMajor Depressive Disorder connects-toVenous Thromboembolism connects-toEpilepsy connects-toAspergillus Fumigatus connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toEndocrine System connects-toCardiovascular System connects-toRespiratory System connects-toRenal System connects-toLymphatic System connects-toDicer1 Syndrome connects-toBirt Hogg Dube Syndrome connects-toTuberous Sclerosis Complex connects-toTargeted Therapy connects-toCortical Bone connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toMelanoma connects-toPeutz Jeghers Syndrome connects-toFap connects-toMyocardium connects-toCarney Complex connects-toBloom Syndrome connects-toHippocampus connects-toWerner Syndrome connects-toNotch connects-toYap1 connects-toPten connects-toMyc connects-toEzh2 connects-toHif 1Alpha connects-toPdgf connects-toErk1 2 connects-toIgf 1 connects-toCaspase 3 connects-toRb1 connects-toEgfr connects-toCalcium connects-toPerforin connects-toRankl connects-toCdk4 6 connects-toE2F1 connects-toPik3Ca connects-toKras connects-toNfe2L2 connects-toIl 6 connects-toJak1 2 connects-toTgf Beta connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toPd 1 connects-toAxl Receptor connects-toIl 10 connects-toTroponin Complex connects-toNitric Oxide connects-toCholesterol connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toCopper connects-toProstaglandins connects-toZinc connects-toSelenium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toDendritic Cell connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toIron connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources