Atlas One · Host Biology · Scale 03 — Molecular

YAP1

YAP1 (Yes-Associated Protein 1) is a transcriptional co-activator held cytoplasmic by LATS1/2-mediated Ser127 phosphorylation; NF2/merlin LOF → LATS inactive → nuclear YAP1-TEAD → CTGF/CYR61/survivin target genes; oncogenic in mesothelioma, schwannoma, and KRAS-mutant tumors.

Also known as: YAP1, YAP, Yes-Associated Protein 1, YAP1 Hippo, YAP TEAD, YAP1 NF2, YAP1 mesothelioma, YAP1 mechanosensing, Hippo YAP effector

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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yap1

YAP1

YAP1 (Yes-Associated Protein 1) is a transcriptional co-activator held cytoplasmic by LATS1/2-mediated Ser127 phosphorylation; NF2/merlin LOF → LATS inactive → nuclear YAP1-TEAD → CTGF/CYR61/survivin target genes; oncogenic in mesothelioma, schwannoma, and KRAS-mutant tumors.

Entry Metadata

FieldValue
IDyap1
NameYAP1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toNf2 connects-toNeurofibromatosis Type 2 connects-toMesothelioma connects-toMyc

Sources