Atlas One · Host Biology · Scale 07 — System

Mesothelioma

Malignant mesothelioma arises from pleural/peritoneal mesothelial cells; asbestos exposure causes ~80% with 30-50-year latency; BAP1 (~55%) and NF2 (~40%) loss define molecular subtypes. Nivolumab+ipilimumab (CheckMate 743: OS 18.1 vs 14.1 months) is first-line standard.

Also known as: mesothelioma, malignant pleural mesothelioma, MPM, peritoneal mesothelioma, asbestos cancer, epithelioid mesothelioma, sarcomatoid mesothelioma, biphasic mesothelioma, Krenning mesothelioma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
mesothelioma

Mesothelioma

Malignant mesothelioma arises from pleural/peritoneal mesothelial cells; asbestos exposure causes ~80% with 30-50-year latency; BAP1 (~55%) and NF2 (~40%) loss define molecular subtypes. Nivolumab+ipilimumab (CheckMate 743: OS 18.1 vs 14.1 months) is first-line standard.

Entry Metadata

FieldValue
IDmesothelioma
NameMesothelioma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBap1 connects-toPd 1 connects-toVegf connects-toPten connects-toNf2 connects-toLung connects-toNlrp3 Inflammasome connects-toMeningioma connects-toT Cytotoxic Cell connects-toUveal Melanoma connects-toRenal Cell Carcinoma connects-toMacrophage connects-toCholangiocarcinoma connects-toNsclc connects-toPhoton connects-toOvarian Cancer connects-toCdkn2A connects-toFibroblast connects-toImmune System connects-toRespiratory System connects-toP53 connects-toCarbon connects-toCtla 4 connects-toFibrosis connects-toIron connects-toYap1 connects-toMagnesium connects-toRegulatory T Cell connects-toHeart connects-toHif 1Alpha connects-toDendritic Cell connects-toLarge Intestine connects-toEndothelial Cell connects-toOxygen connects-toElectron connects-toWt1 connects-toPlatelet connects-toLiver connects-toBone Marrow connects-toCalcium connects-toAntibody connects-toNeutrophil connects-toErythrocyte connects-toMtor connects-toReproductive System connects-toMast Cell connects-toTert connects-toWnt Beta Catenin connects-toNatural Killer Cell connects-toIl 6 connects-toVenous Thromboembolism connects-toHeart Failure connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toNeuropathic Pain connects-toCkd connects-toMajor Depressive Disorder connects-toAspergillus Fumigatus connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toIntegumentary System connects-toMusculoskeletal System connects-toLymphatic System connects-toCardiovascular System connects-toNervous System connects-toRenal System connects-toTargeted Therapy connects-toEndocrine System connects-toCancer Chemotherapy connects-toSynovial Sarcoma connects-toMelanoma connects-toCheckpoint Inhibitors connects-toAlveolus connects-toBreast Cancer connects-toNeurofibromatosis Type 2 connects-toMyocardium connects-toGerminal Center connects-toTuberculosis connects-toIntestinal Epithelium connects-toCortical Bone connects-toEzh2 connects-toEgfr connects-toMyc connects-toAkt connects-toCyclin D1 connects-toPdgf connects-toIl 1B connects-toTgf Beta connects-toCcl2 connects-toRage connects-toCxcl12 connects-toCaspase 3 connects-toPerforin connects-toSrc Kinase connects-toRad51 connects-toCdk4 6 connects-toPik3Ca connects-toTnf Alpha connects-toNf Kb connects-toNfe2L2 connects-toErk1 2 connects-toGalectin 3 connects-toJak1 2 connects-toSmad4 connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toDnmt3A connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toNotch connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toAxl Receptor connects-toXanthine Oxidase connects-toHemoglobin connects-toIl 10 connects-toProstaglandins connects-toIl 4 connects-toNitric Oxide connects-toIl 13 connects-toLarge Intestine connects-toSmall Intestine connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toComplement C5 connects-toC5Ar1 connects-toT Helper Cell connects-toB Cell connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTslp connects-toPeriostin connects-toHistamine connects-toBradykinin connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toNitrogen connects-toSulfur connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin