Atlas One · Host Biology · Scale 07 — System

Mesothelioma

Malignant mesothelioma arises from pleural/peritoneal mesothelial cells; asbestos exposure causes ~80% with 30-50-year latency; BAP1 (~55%) and NF2 (~40%) loss define molecular subtypes. Nivolumab+ipilimumab (CheckMate 743: OS 18.1 vs 14.1 months) is first-line standard.

Also known as: mesothelioma, malignant pleural mesothelioma, MPM, peritoneal mesothelioma, asbestos cancer, epithelioid mesothelioma, sarcomatoid mesothelioma, biphasic mesothelioma, Krenning mesothelioma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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mesothelioma

Mesothelioma

Malignant mesothelioma arises from pleural/peritoneal mesothelial cells; asbestos exposure causes ~80% with 30-50-year latency; BAP1 (~55%) and NF2 (~40%) loss define molecular subtypes. Nivolumab+ipilimumab (CheckMate 743: OS 18.1 vs 14.1 months) is first-line standard.

Entry Metadata

FieldValue
IDmesothelioma
NameMesothelioma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBap1 connects-toPd 1 connects-toVegf connects-toPten connects-toNf2 connects-toLung connects-toNlrp3 Inflammasome connects-toMeningioma connects-toT Cytotoxic Cell connects-toUveal Melanoma connects-toRenal Cell Carcinoma connects-toMacrophage connects-toCholangiocarcinoma

Sources