Atlas One · Host Biology · Scale 07 — System

Uveal Melanoma

Uveal melanoma is the most common primary intraocular malignancy; GNAQ/GNA11 ~85%, BAP1 ~45%, SF3B1 R625 ~15-20%, EIF1AX ~15%; Class 2 (BAP1 loss) has 25-35% 5-year metastasis-free survival; tebentafusp (gp100×CD3) is FDA-approved for HLA-A*02:01+ metastatic disease.

Also known as: uveal melanoma, choroidal melanoma, iris melanoma, ciliary body melanoma, intraocular melanoma, ocular melanoma, GNAQ melanoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
uveal-melanoma

Uveal Melanoma

Uveal melanoma is the most common primary intraocular malignancy; GNAQ/GNA11 ~85%, BAP1 ~45%, SF3B1 R625 ~15-20%, EIF1AX ~15%; Class 2 (BAP1 loss) has 25-35% 5-year metastasis-free survival; tebentafusp (gp100×CD3) is FDA-approved for HLA-A*02:01+ metastatic disease.

Entry Metadata

FieldValue
IDuveal-melanoma
NameUveal Melanoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSf3B1 connects-toBap1 connects-toPten connects-toPd 1 connects-toMelanoma connects-toYap1 connects-toBraf connects-toEye connects-toLiver connects-toT Cytotoxic Cell connects-toMesothelioma connects-toNeurofibromatosis Type 2 connects-toPhoton connects-toRetinoblastoma connects-toCholangiocarcinoma connects-toRenal Cell Carcinoma connects-toVegf connects-toImmune System connects-toNatural Killer Cell connects-toEndothelial Cell connects-toFibroblast connects-toT Helper Cell connects-toErk1 2 connects-toMacrophage connects-toTert connects-toCalcium connects-toRegulatory T Cell connects-toAkt connects-toOxygen connects-toLung connects-toDendritic Cell connects-toCopper connects-toSkin connects-toBrain connects-toElectron connects-toPlatelet connects-toBone Marrow connects-toNeuron connects-toCollagen connects-toNeutrophil connects-toAntibody connects-toHepatocyte connects-toErythrocyte connects-toProton connects-toReproductive System connects-toHif 1Alpha connects-toCtla 4 connects-toMtor connects-toMast Cell connects-toStat3 connects-toNf Kb connects-toVenous Thromboembolism connects-toCytokine Storm connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toType 1 Diabetes connects-toHeart Failure connects-toCkd connects-toDigestive System connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toIntegumentary System connects-toLymphatic System connects-toMusculoskeletal System connects-toNervous System connects-toCardiovascular System connects-toTargeted Therapy connects-toEndocrine System connects-toToxoplasma Gondii connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toHepatic Lobule connects-toGerminal Center connects-toMds connects-toHcc connects-toArterial Wall connects-toSynovial Sarcoma connects-toBreast Cancer connects-toCll connects-toAlveolus connects-toCortical Bone connects-toEzh2 connects-toCyclin D1 connects-toMyc connects-toMet connects-toPdgf connects-toCcl2 connects-toMdm2 connects-toCxcl12 connects-toAxl Receptor connects-toPerforin connects-toIgf 1 connects-toEndothelin 1 connects-toPik3Ca connects-toBcl 2 connects-toNotch connects-toE2F1 connects-toCdkn2A connects-toCdh1 connects-toRb1 connects-toJak1 2 connects-toIl 6 connects-toCgas Sting connects-toStat1 connects-toGalectin 3 connects-toSmad4 connects-toFoxo connects-toCdk4 6 connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toCalcineurin connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toMhc Class Ii connects-toP53 connects-toCaspase 3 connects-toIl 2 connects-toTroponin Complex connects-toHemoglobin connects-toIl 10 connects-toNitric Oxide connects-toXanthine Oxidase connects-toIl 4 connects-toTgf Beta connects-toIron connects-toIl 13 connects-toZinc connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toB Cell connects-toComplement C5 connects-toC5Ar1 connects-toComplement C3 connects-toFactor H connects-toTransferrin connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin

Sources