Atlas One · Host Biology · Scale 07 — System

Uveal Melanoma

Uveal melanoma is the most common primary intraocular malignancy; GNAQ/GNA11 ~85%, BAP1 ~45%, SF3B1 R625 ~15-20%, EIF1AX ~15%; Class 2 (BAP1 loss) has 25-35% 5-year metastasis-free survival; tebentafusp (gp100×CD3) is FDA-approved for HLA-A*02:01+ metastatic disease.

Also known as: uveal melanoma, choroidal melanoma, iris melanoma, ciliary body melanoma, intraocular melanoma, ocular melanoma, GNAQ melanoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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uveal-melanoma

Uveal Melanoma

Uveal melanoma is the most common primary intraocular malignancy; GNAQ/GNA11 ~85%, BAP1 ~45%, SF3B1 R625 ~15-20%, EIF1AX ~15%; Class 2 (BAP1 loss) has 25-35% 5-year metastasis-free survival; tebentafusp (gp100×CD3) is FDA-approved for HLA-A*02:01+ metastatic disease.

Entry Metadata

FieldValue
IDuveal-melanoma
NameUveal Melanoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSf3B1 connects-toBap1 connects-toPten connects-toPd 1 connects-toMelanoma connects-toYap1 connects-toBraf connects-toEye connects-toLiver connects-toT Cytotoxic Cell

Sources