Atlas One · Host Biology · Scale 07 — System

Hepatocellular Carcinoma

Primary liver malignancy arising on a background of cirrhosis (HBV, HCV, alcohol, NAFLD); VEGF-driven neoangiogenesis targeted by sorafenib and lenvatinib; atezolizumab+bevacizumab is preferred first-line; CTNNB1 mutations (~30%) and TP53 mutations (~30%) are most common.

Also known as: HCC, hepatocellular carcinoma, liver cancer, primary liver cancer, hepatoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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hcc

Hepatocellular Carcinoma

Primary liver malignancy arising on a background of cirrhosis (HBV, HCV, alcohol, NAFLD); VEGF-driven neoangiogenesis targeted by sorafenib and lenvatinib; atezolizumab+bevacizumab is preferred first-line; CTNNB1 mutations (~30%) and TP53 mutations (~30%) are most common.

Entry Metadata

FieldValue
IDhcc
NameHepatocellular Carcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVegf connects-toMtor connects-toWnt Beta Catenin connects-toPd 1 connects-toHepatitis C connects-toHepatitis B connects-toLiver connects-toHepatocyte connects-toTert connects-toAlcohol Use Disorder connects-toObesity connects-toCholangiocarcinoma

Sources