Atlas One · Host Biology · Scale 07 — System

Hepatocellular Carcinoma

Primary liver malignancy arising on a background of cirrhosis (HBV, HCV, alcohol, NAFLD); VEGF-driven neoangiogenesis targeted by sorafenib and lenvatinib; atezolizumab+bevacizumab is preferred first-line; CTNNB1 mutations (~30%) and TP53 mutations (~30%) are most common.

Also known as: HCC, hepatocellular carcinoma, liver cancer, primary liver cancer, hepatoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hcc

Hepatocellular Carcinoma

Primary liver malignancy arising on a background of cirrhosis (HBV, HCV, alcohol, NAFLD); VEGF-driven neoangiogenesis targeted by sorafenib and lenvatinib; atezolizumab+bevacizumab is preferred first-line; CTNNB1 mutations (~30%) and TP53 mutations (~30%) are most common.

Entry Metadata

FieldValue
IDhcc
NameHepatocellular Carcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVegf connects-toMtor connects-toWnt Beta Catenin connects-toPd 1 connects-toHepatitis C connects-toHepatitis B connects-toLiver connects-toHepatocyte connects-toTert connects-toAlcohol Use Disorder connects-toObesity connects-toCholangiocarcinoma connects-toNash connects-toType 2 Diabetes connects-toT Cytotoxic Cell connects-toPhoton connects-toMacrophage connects-toRenal Cell Carcinoma connects-toP53 connects-toFibrosis connects-toIron connects-toLung connects-toEndothelial Cell connects-toImmune System connects-toCtla 4 connects-toNatural Killer Cell connects-toCarbon connects-toSpleen connects-toNf Kb connects-toIl 6 connects-toOxygen connects-toRegulatory T Cell connects-toAdrenal Gland connects-toSodium connects-toHeart connects-toBone Marrow connects-toElectron connects-toCopper connects-toPlatelet connects-toNeuron connects-toErythrocyte connects-toCalcium connects-toAntibody connects-toNeutrophil connects-toReproductive System connects-toFibroblast connects-toTgf Beta connects-toAspergillus Fumigatus connects-toCtnnb1 connects-toDendritic Cell connects-toVenous Thromboembolism connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toCkd connects-toHypertension connects-toMajor Depressive Disorder connects-toHeart Failure connects-toOsteoporosis connects-toType 1 Diabetes connects-toDigestive System connects-toNervous System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toEndocrine System connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toIntegumentary System connects-toCheckpoint Inhibitors connects-toTargeted Therapy connects-toHepatitis B Virus connects-toCancer Chemotherapy connects-toHepatic Lobule connects-toAspirin connects-toAlveolus connects-toHif 1Alpha connects-toKidney connects-toUveal Melanoma connects-toPolycythemia Vera connects-toCortical Bone connects-toArterial Wall connects-toPulmonary Arterial Hypertension connects-toColorectal Cancer connects-toMyc connects-toAkt connects-toCyclin D1 connects-toMet connects-toFgfr connects-toCcl2 connects-toArid1A connects-toAxl Receptor connects-toTlr4 connects-toCgas Sting connects-toAndrogen Receptor connects-toHepcidin connects-toErk1 2 connects-toPik3Ca connects-toPdgf connects-toNfe2L2 connects-toMyd88 connects-toOsteopontin connects-toSmad4 connects-toJak1 2 connects-toCdkn2A connects-toGalectin 3 connects-toStat1 connects-toEzh2 connects-toFoxo connects-toCdk4 6 connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toMhc Class Ii connects-toEstrogen connects-toIgf 1 connects-toCollagen connects-toIl 2 connects-toHemoglobin connects-toIl 10 connects-toNitric Oxide connects-toXanthine Oxidase connects-toIl 4 connects-toLeptin connects-toProstaglandins connects-toIl 13 connects-toAdiponectin connects-toCopper connects-toFibroblast connects-toT Cytotoxic Cell connects-toHepatitis C connects-toIfn Gamma connects-toIl 12 connects-toResistin connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toComplement C3 connects-toC5Ar1 connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toZinc connects-toMagnesium connects-toIodine connects-toPotassium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toActivin A connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toCgrp connects-toAldosterone connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin

Sources