Atlas One · Host Biology · Scale 07 — System

Polycythemia Vera

Polycythemia vera is a JAK2-driven MPN with erythrocytosis, thrombocytosis, and leukocytosis; JAK2 V617F ~99%; phlebotomy + low-dose aspirin for all; hydroxyurea or ropeginterferon alfa-2b for high-risk; ruxolitinib for HU-resistant; MF/AML transformation risk.

Also known as: polycythemia vera, PV, polycythaemia vera, primary polycythemia, JAK2 V617F polycythemia, polycythemia rubra vera

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
polycythemia-vera

Polycythemia Vera

Polycythemia vera is a JAK2-driven MPN with erythrocytosis, thrombocytosis, and leukocytosis; JAK2 V617F ~99%; phlebotomy + low-dose aspirin for all; hydroxyurea or ropeginterferon alfa-2b for high-risk; ruxolitinib for HU-resistant; MF/AML transformation risk.

Entry Metadata

FieldValue
IDpolycythemia-vera
NamePolycythemia Vera
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toEpas1 connects-toJak2 connects-toErythropoietin connects-toTgf Beta connects-toMyeloproliferative Neoplasms connects-toErythrocyte connects-toSpleen connects-toStroke connects-toEssential Thrombocythemia connects-toBone Marrow connects-toMyelofibrosis connects-toVenous Thromboembolism connects-toAml connects-toGout connects-toCkd connects-toRenal Cell Carcinoma connects-toOxygen connects-toIron Deficiency Anemia connects-toCml connects-toIron connects-toPlatelet connects-toCardiovascular System connects-toLiver connects-toMast Cell connects-toStat3 connects-toHemoglobin connects-toHistamine connects-toNeutrophil connects-toBrain connects-toSkin connects-toPotassium connects-toHeart connects-toEye connects-toEndothelial Cell connects-toElectron connects-toKidney connects-toLung connects-toNeuron connects-toJak1 2 connects-toVhl Disease connects-toPhosphorus connects-toHepatocyte connects-toReproductive System connects-toAtherosclerosis connects-toOsteoblast connects-toAkt connects-toHepcidin connects-toTet2 connects-toPulmonary Arterial Hypertension connects-toNlrp3 Inflammasome connects-toMds connects-toHypertension connects-toTnf Alpha connects-toNf Kb connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toMajor Depressive Disorder connects-toSepsis connects-toVaricella Zoster Virus connects-toAspergillus Fumigatus connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toDigestive System connects-toNervous System connects-toLymphatic System connects-toRespiratory System connects-toEndocrine System connects-toAspirin connects-toMusculoskeletal System connects-toRenal System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toMycobacterium Tuberculosis connects-toArterial Wall connects-toHepatic Lobule connects-toCopd connects-toMyocardium connects-toAntiphospholipid Syndrome connects-toPeripheral Nerve connects-toVon Willebrand Factor connects-toHcc connects-toPheochromocytoma Paraganglioma connects-toType I Interferon connects-toHif 1Alpha connects-toEzh2 connects-toIl 6 connects-toIl 1B connects-toVegf connects-toPf4 connects-toXanthine Oxidase connects-toPdgf connects-toCalr connects-toThrombin connects-toSf3B1 connects-toErk1 2 connects-toDnmt3A connects-toFerroportin connects-toPik3Ca connects-toMtor connects-toP53 connects-toMyd88 connects-toCdkn2A connects-toRunx1 connects-toStat1 connects-toGalectin 3 connects-toPten connects-toCgas Sting connects-toSmad4 connects-toCdk4 6 connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toMdm2 connects-toPerforin connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toCxcl12 connects-toArid1A connects-toIl 33 connects-toEgln1 connects-toTransferrin connects-toNitric Oxide connects-toTroponin Complex connects-toSerotonin connects-toEndothelin 1 connects-toAdamts13 connects-toProtein C connects-toIl 10 connects-toProstaglandins connects-toAngiopoietin connects-toFibrinogen connects-toIl 4 connects-toLeptin connects-toAdiponectin connects-toIl 13 connects-toResistin connects-toMacrophage connects-toT Cytotoxic Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toDendritic Cell connects-toComplement C5 connects-toC5Ar1 connects-toComplement C3 connects-toFactor H connects-toNatural Killer Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toCalcium connects-toZinc connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr