Atlas One · Host Biology · Scale 03 — Molecular

CALR

CALR encodes calreticulin (ER chaperone); exon 9 frameshift mutations generate a novel C-terminus that activates MPL → constitutive JAK-STAT signaling; CALR mutations occur in ~25% ET and ~20-25% PMF; type 1 del52 → PMF phenotype; type 2 ins5 → ET phenotype.

Also known as: CALR, calreticulin, CALR exon 9 mutation, CALR type 1, CALR type 2, CALR MPN, calreticulin MPN, calreticulin myelofibrosis

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
calr

CALR

CALR encodes calreticulin (ER chaperone); exon 9 frameshift mutations generate a novel C-terminus that activates MPL → constitutive JAK-STAT signaling; CALR mutations occur in ~25% ET and ~20-25% PMF; type 1 del52 → PMF phenotype; type 2 ins5 → ET phenotype.

Entry Metadata

FieldValue
IDcalr
NameCALR
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toJak2 connects-toJak1 2 connects-toStat3 connects-toMtor connects-toMpl connects-toMyelofibrosis connects-toEssential Thrombocythemia

Sources